Details:

Alternative Title:
Occup Environ Med
Personal Author:
Cavallari, Jennifer M. ; Fang, Shona C. ; Eisen, Ellen A. ; Mittleman, Murray A. ; Christiani, David C.
Cavallari, Jennifer M. ; Fang, Shona C. ; Eisen, Ellen A. ; Mittleman, Murray A. ; Christiani, David C. Less -
Description:
Objectives

Links between arrhythmias and particulate matter exposures have been found among sensitive populations. We examined the relationship between personal PM2.5 (particulate matter ≤ 2.5μm aerodynamic diameter) exposures and ectopy in a panel study of healthy welders.

Methods

Simultaneous ambulatory electrocardiogram (ECG) and personal PM2.5 exposure monitoring with DustTrak™ Aerosol Monitor was performed on 72 males during work and non-work periods for 5–90 hours (median 40 hours). ECGs were summarized hourly for supraventricular ectopy (SVE) and ventricular ectopy (VE). PM2.5 exposures both work and non-work periods were averaged hourly with lags from 0- to 7-hours. Generalized linear mixed-effects models with a random participant intercept were used to examine the relationship between PM2.5 exposure and the odds of SVE or VE. Sensitivity analyses were performed to assess whether relationships differed by work period and current smokers.

Results

Participants had a mean(SD) age of 38(11) years and were monitored over 2,993 person-hours. The number of hourly ectopic events was highly skewed with mean(sd) of 14(69) VE and 1(4) SVE. We found marginally significant increases in VE with PM2.5 exposures in the 6th and 7th hour lags, yet no association with SVE. For every 100μg/m3 increase in 6th hour lagged PM2.5, the adjusted OR(95% CI) for VE was 1.03(1.00, 1.05). Results persisted in work or non-work exposure periods and non-smokers had increased odds of VE associated with PM2.5 as compared to smokers.

Conclusions

A small increase in the odds of ventricular ectopy with short term PM2.5 exposure was observed among relatively healthy men with environmental and occupational exposures.


Subject:
[+]
Adult
Air Pollutants
Article
Cardiovascular
Ectopy
Electrocardiography, Ambulatory
Environmental Exposure
Environmental Monitoring
Heart Rate
Humans
Linear Models
Longitudinal Studies
Male
Middle Aged
Occupational Exposure
Particulate Matter
Risk Factors
Self Report
Smoking
Tachycardia
Ventricular Premature Complexes
Welding
Young Adult
Welding

Source:
Occup Environ Med. 73(7):435-441.
Pubmed ID:
27052768
Pubmed Central ID:
PMC4948285
Document Type:
Journal Article
Funding:
P30 ES000002/ES/NIEHS NIH HHS/United States ; R01 ES009860/ES/NIEHS NIH HHS/United States ; T32 ES007069/ES/NIEHS NIH HHS/United States ; T42 OH008416/OH/NIOSH CDC HHS/United States
P30 ES000002/ES/NIEHS NIH HHS/United States ; R01 ES009860/ES/NIEHS NIH HHS/United States ; T32 ES007069/ES/NIEHS NIH HHS/United States ; T42 OH008416/OH/NIOSH CDC HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:16544218ec9d3e2bec13c98da9252ee97a66cb81a4fa0dd4bd278a0915e9c5e9
File Type:

Supporting Files

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