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Blood group A and Rh(D)-negativity are associated with symptomatic West Nile virus infection
  • Published Date:
    May 18 2016
  • Source:
    Transfusion. 56(7):1699-1706.


Public Access Version Available on: July 01, 2017 information icon
Please check back on the date listed above.
Details:
  • Pubmed ID:
    27189860
  • Pubmed Central ID:
    PMC4938756
  • Funding:
    R01 CI000214/CI/NCPDCID CDC HHS/United States
    RC2 HL101632/HL/NHLBI NIH HHS/United States
  • Document Type:
  • Collection(s):
  • Description:
    Background

    West Nile virus (WNV) infection is mostly asymptomatic but 20% of subjects report WNV fever and 1% of patients experience neurological diseases with higher rates in elderly and immunosuppressed persons. With no treatment and no vaccine to prevent the development of symptomatic infections, it is essential to understand prognostic factors influencing symptomatic disease outcome. Host genetic background has been linked to the development of WNV neuroinvasive disease. The present study investigates the association between the ABO and Rh(D) blood group status and WNV disease outcome.

    Study Design and Methods

    The distribution of blood groups was investigated within a cohort of 374 WNV+ blood donors including 244 asymptomatic (AS) and 130 symptomatic (S) WNV+ blood donors. Logistic regression analyses were used to examine associations between A, B, O and Rh(D) blood groups and WNV clinical disease outcome.

    Results

    Symptomatic WNV+ donors exhibited increased frequencies of blood group A (S 47.6% AS 36.8%, P=0.04, OR [95%CI] 1.56 [1.01–2.40]) and Rh(D)-negative individuals (S 21.5% AS 13.1%, P=0.03, OR [95%CI] 1.82 [1.04–3.18]).

    Conclusion

    The findings suggest a genetic susceptibility placing blood group A and Rh(D)-negative individuals at risk for the development of symptomatic disease outcome after WNV infection.

  • Supporting Files:
    No Additional Files