Acanthamoeba Keratitis among Rigid Gas Permeable Contact Lens Wearers, United States, 2005–2011
Advanced Search
Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.

Search our Collections & Repository

All these words:

For very narrow results

This exact word or phrase:

When looking for a specific result

Any of these words:

Best used for discovery & interchangable words

None of these words:

Recommended to be used in conjunction with other fields



Publication Date Range:


Document Data


Document Type:






Clear All

Query Builder

Query box

Clear All

For additional assistance using the Custom Query please check out our Help Page


Acanthamoeba Keratitis among Rigid Gas Permeable Contact Lens Wearers, United States, 2005–2011

Filetype[PDF-89.37 KB]

  • English

  • Details:

    • Alternative Title:
    • Description:

      To describe the clinical presentation and outcomes of Acanthamoeba keratitis (AK) in rigid gas permeable (RGP) contact lens wearers and identify modifiable risk factors.


      A case-control investigation.


      Case-patients were RGP contact lens-wearing U.S. residents with a diagnosis of AK during 2005–2011. Controls were RGP contact lens wearers with no history of AK and at least 12 years of age.


      Case-patients were identified during two multi-state AK outbreak investigations. Controls from the first investigation in 2007 were identified using a reverse address directory. In the second investigation, controls were recruited from participating ophthalmology and optometry practices. Case-patients and controls were interviewed by phone using a standardized questionnaire. Odds ratios (ORs) and Fisher’s exact P-values were calculated to assess risk factors associated with infection.

      Main Outcome Measures

      AK, a rare eye disease primarily affecting contact lens wearers, is caused by free-living amebae, Acanthamoeba spp.


      We identified 37 case-patients in the two investigations, 10 (27%) from the 2007 investigation and 27 (73%) from 2011. There were 17 healthy controls, 9 (53%) from 2007 and 8 (47%) from 2011. Among case-patients, 9 (24%) wore RGP lenses for orthokeratology or therapeutic indication; no controls wore RGP lenses for these indications. Significant risk factors for AK were wearing lenses for orthokeratology (OR undefined, P=0.02), sleeping while wearing lenses (OR 8.00, P=0.04), storing lenses in tap water (OR 16.00, P=0.001), and topping off contact lens solution in the case (OR 4.80, P=0.01). After stratifying by use of RGP lenses for orthokeratology, storing lenses in tap water and topping off remained significant exposures.


      Nearly a quarter of case-patients were orthokeratology wearers. Using tap water to store RGP lenses and topping off solution in the lens case were modifiable risk behaviors identified in RGP wearers who wore lenses for both orthokeratology and non-orthokeratology indications. RGP wearers should avoid exposing their lenses to tap water and should empty their cases and use fresh lens solution each time they take out their lenses.

    • Pubmed ID:
    • Pubmed Central ID:
    • Document Type:
    • Collection(s):
    • Main Document Checksum:
    • File Type:

    Supporting Files

    More +

    You May Also Like

    Checkout today's featured content at