i
Lack of periconceptional vitamins or supplements that contain folic acid and diabetes mellitus–associated birth defects
-
Dec 27 2011
-
-
Source: Am J Obstet Gynecol. 206(3):218.e1-218.13.
[PDF-176.69 KB]
Details:
-
Alternative Title:Am J Obstet Gynecol
-
Personal Author:
-
Corporate Authors:
-
Description:OBJECTIVE
The purpose of this study was to examine the risk of birth defects in relation to diabetes mellitus and the lack of use of periconceptional vitamins or supplements that contain folic acid.
STUDY DESIGN
The National Birth Defects Prevention Study (1997-2004) is a multicenter, population-based case-control study of birth defects (14,721 cases and 5437 control infants). Cases were categorized into 18 types of heart defects and 26 noncardiac birth defects. We estimated odds ratios for independent and joint effects of preexisting diabetes mellitus and a lack of periconceptional use of vitamins or supplements that contain folic acid.
RESULTS
The pattern of odds ratios suggested an increased risk of defects that are associated with diabetes mellitus in the absence vs the presence of the periconceptional use of vitamins or supplements that contain folic acid.
CONCLUSION
The lack of periconceptional use of vitamins or supplements that contain folic acid may be associated with an excess risk for birth defects due to diabetes mellitus.
-
Subjects:
-
Source:
-
Pubmed ID:22284962
-
Pubmed Central ID:PMC4915337
-
Document Type:
-
Funding:
-
Volume:206
-
Issue:3
-
Collection(s):
-
Main Document Checksum:
-
Download URL:
-
File Type:
