Lack of periconceptional vitamins or supplements that contain folic acid and diabetes mellitus–associated birth defects
Published Date:Dec 27 2011
Source:Am J Obstet Gynecol. 206(3):218.e1-218.13.
Corporate Authors:for the National Birth Defects Prevention Study
Pubmed Central ID:PMC4915337
Funding:02081/PHS HHS/United States
U50 DD113247/DD/NCBDD CDC HHS/United States
U50 DD223184/DD/NCBDD CDC HHS/United States
U50 DD422096/DD/NCBDD CDC HHS/United States
U50 DD613232/DD/NCBDD CDC HHS/United States
U50 DD613236/DD/NCBDD CDC HHS/United States
U50 DD713238/DD/NCBDD CDC HHS/United States
U50 DD822097/DD/NCBDD CDC HHS/United States
U50 DD913241/DD/NCBDD CDC HHS/United States
The purpose of this study was to examine the risk of birth defects in relation to diabetes mellitus and the lack of use of periconceptional vitamins or supplements that contain folic acid.
The National Birth Defects Prevention Study (1997-2004) is a multicenter, population-based case-control study of birth defects (14,721 cases and 5437 control infants). Cases were categorized into 18 types of heart defects and 26 noncardiac birth defects. We estimated odds ratios for independent and joint effects of preexisting diabetes mellitus and a lack of periconceptional use of vitamins or supplements that contain folic acid.
The pattern of odds ratios suggested an increased risk of defects that are associated with diabetes mellitus in the absence vs the presence of the periconceptional use of vitamins or supplements that contain folic acid.
The lack of periconceptional use of vitamins or supplements that contain folic acid may be associated with an excess risk for birth defects due to diabetes mellitus.
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