Allergic Potential and Immunotoxicity Induced by Topical Application of 1-Chloro-4-(Trifluoromethyl)Benzene (PCBTF) in a Murine Model

Details

• Alternative Title:
  J Allergy (Cairo)
• Personal Author:
  Franko, Jennifer ; Jackson, Laurel G. ; Meade, B. Jean ; Anderson, Stacey E.
• Description:
  The purpose of the studies in this paper was to evaluate the allergic potential, immunotoxicity, and irritancy of the occupationally relevant chemical, 1-chloro-4-(trifluoromethyl)benzene, also known as parachlorobenzotrifluoride (PCBTF), following dermal exposure in a murine model. Evaluation of the sensitization potential, conducted using the local lymph node assay (LLNA) at concentrations ranging from 50% to 100%, identified a dose-dependent increase in lymphocyte proliferation with a calculated EC3 value of 53.1%. While no elevations in total or specific IgE were observed after exposure to any concentration of the chemical, significant increases in IFN-γ protein production by stimulated draining lymphoid cells were observed, indicating a T-cell-mediated response. Dermal exposure to PCBTF was not found to alter the immune response to a T-cell-dependant antigen. These results demonstrate that PCBTF has the potential to induce allergic sensitization following dermal exposure and based on LLNA results would be classified as a weak sensitizer.
• Subjects:
  Research Article
• Source:
  J Allergy (Cairo). 2011; 2011.
• Document Type:
  Journal Article
• Volume:
  2011
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:dbed2586ff1591fbb2a376c06ea799f9964e1eee9c940f75c834a305ddb31d5a
• Download URL:
  https://stacks.cdc.gov/view/cdc/4024/cdc_4024_DS1.pdf
• File Type:
  [PDF - 670.33 KB ]