Details:

Alternative Title:
PLoS One
Publisher's site:
http://dx.doi.org/10.1371/journal.pone.0156987
Personal Author:
Marston, Chung K. ; Ibrahim, Hisham ; Lee, Philip ; Churchwell, George ; Gumke, Megan ; ... More +
Marston, Chung K. ; Ibrahim, Hisham ; Lee, Philip ; Churchwell, George ; Gumke, Megan ; Stanek, Danielle ; Gee, Jay E. ; Boyer, Anne E. ; Gallegos-Candela, Maribel ; Barr, John R. ; Li, Han ; Boulay, Darbi ; Cronin, Li ; Quinn, Conrad P. ; Hoffmaster, Alex R. ; Less -
Description:
Bacillus cereus isolates have been described harboring Bacillus anthracis toxin genes, most notably B. cereus G9241, and capable of causing severe and fatal pneumonias. This report describes the characterization of a B. cereus isolate, BcFL2013, associated with a naturally occurring cutaneous lesion resembling an anthrax eschar. Similar to G9241, BcFL2013 is positive for the B. anthracis pXO1 toxin genes, has a multi-locus sequence type of 78, and a pagA sequence type of 9. Whole genome sequencing confirms the similarity to G9241. In addition to the chromosome having an average nucleotide identity of 99.98% when compared to G9241, BcFL2013 harbors three plasmids with varying homology to the G9241 plasmids (pBCXO1, pBC210 and pBFH_1). This is also the first report to include serologic testing of patient specimens associated with this type of B. cereus infection which resulted in the detection of anthrax lethal factor toxemia, a quantifiable serum antibody response to protective antigen (PA), and lethal toxin neutralization activity.
Subject:
[+]
Aged
Anthrax
Antigens, Bacterial
Bacillus Cereus
Bacterial Toxins
Humans
Male

Source:
PLoS One. 11(6). ;
Pubmed ID:
27257909
Pubmed Central ID:
PMC4892579
Document Type:
Journal Article ;
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:87c80f5ac89336c3108425086187b68e2fd46462a2a8b799571a34675986d56a
File Type:

Supporting Files

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