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Alert to U.S. healthcare facilities : first mcr-1 gene in E. coli bacteria found in a human in the United States
  • Published Date:
    June 13, 2016
  • Series:
    HAN ; 390
  • Language:
Filetype[PDF-62.38 KB]

  • Description:
    June 13, 2016, 13:35 EDT (1:35 PM EDT)


    The Centers for Disease Control and Prevention (CDC) is collaborating in a coordinated public health

    response to the Department of Defense (DoD) announcement on May 26 of the first mcr-1 gene found in bacteria from a human in the United States (http://aac.asm.org/content/early/2016/05/25/AAC.01103-16.full.pdf+html). Escherichia coli (E. coli) bacteria carrying the mcr-1 gene were found in a urine sample from a person in Pennsylvania with no recent travel outside of the United States who presented to a clinic with a urinary tract infection. The mcr-1 gene makes bacteria resistant to the antibiotic colistin, which is used as a last-resort drug to treat patients with infections caused by multidrug-resistant bacteria, including carbapenem-resistant Enterobacteriaceae (CRE). The mcr-1 gene exists on a plasmid, a small piece of DNA that is capable of moving from one bacterium to another, potentially spreading antibiotic resistance to other bacterial species. CDC is issuing this HAN notice as a reminder to U.S. healthcare facilities about recommendations to prevent antibiotic resistant infections and alert them to additional recommendations for detecting and reporting bacteria with the mcr-1 gene.

    FINAL HAN 390_First mcr-1 Gene in E. coli in Human in US_06 13 2016.pdf

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