Bacterial microbiome of breast milk and child saliva from low-income Mexican-American women and children

Details

• Alternative Title:
  Pediatr Res
• Personal Author:
  Davé, Veronica ; Street, Kelly ; Francis, Stephen ; Bradman, Asa ; Riley, Lee ; Eskenazi, Brenda ; Holland, Nina
• Description:
  Background
  
  The childhood salivary microbiome, which plays an important role in healthy development, may be influenced by breast milk consumption. The composition of the milk microbiome and the role it plays in the establishment of the infant microbiome are not well understood.
  
  Methods
  
  Here, we sequenced the bacterial 16S rRNA gene to characterize microbial communities in breast milk and 5-year-old child saliva from ten low-income, Mexican-American mother-child pairs with a high prevalence of obesity.
  
  Results
  
  Members of the genus Streptococcus dominated both milk and salivary microbial communities in most subjects. Staphylococcus was observed predominately in milk samples while Prevotella was more prevalent in child saliva. No statistically significant relationships were observed between maternal and child microbiomes or between child microbiome and BMI. However, pre-pregnancy BMI was correlated with both lower Streptococcus abundance (r = −0.67) and higher microbial diversity (r = 0.77) in breast milk (P < 0.05 for both). Diversity estimates were notably similar to data from other low-income cohorts or children.
  
  Conclusion
  
  These findings contribute to the currently-limited state of knowledge regarding the breast milk and salivary microbiomes in mother-child pairs and may inform future studies seeking to elucidate the relationship between early-life microbial exposures and pediatric health.
  
  
• Subjects:
  Adult Article Bacterial Infections Body Mass Index Child Female Food Microbiology Humans Longitudinal Studies Male Mexican Americans Microbiota Milk, Human Obesity Pediatric Obesity Pilot Projects Poverty Prevalence Prevotella RNA, Ribosomal, 16S Saliva Sex Factors Streptococcus United States Young Adult

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• Source:
  Pediatr Res. 79(6):846-854
• Pubmed ID:
  26756784
• Pubmed Central ID:
  PMC4899194
• Document Type:
  Journal Article
• Funding:
  T32 CA151022/CA/NCI NIH HHSUnited States/ ; R01 ES015572/ES/NIEHS NIH HHSUnited States/ ; R01 ES012503/ES/NIEHS NIH HHSUnited States/ ; S10 RR029668/RR/NCRR NIH HHSUnited States/ ; S10 RR027303/RR/NCRR NIH HHSUnited States/ ; R01 OH007400/OH/NIOSH CDC HHSUnited States/ ; P01 ES009605/ES/NIEHS NIH HHSUnited States/
• Volume:
  79
• Issue:
  6
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:8bf9669faa6bd764f0616f43d4df8b4ca9f1b2021dfbbf3b23f252d302bd4a54
• Download URL:
  https://stacks.cdc.gov/view/cdc/39852/cdc_39852_DS1.pdf
• File Type:
  [PDF - 852.20 KB ]