Community-Acquired Pneumonia Hospitalization among Children with Neurologic Disorders

Details

• Alternative Title:
  J Pediatr
• Personal Author:
  Millman, Alexander J. ; Finelli, Lyn ; Bramley, Anna M. ; Peacock, Georgina ; Williams, Derek J. ; Arnold, Sandra R. ; Grijalva, Carlos G. ; Anderson, Evan J. ; McCullers, Jonathan A. ; Ampofo, Krow ; Pavia, Andrew T. ; Edwards, Kathryn M. ; Jain, Seema
• Description:
  Objective
  
  To describe and compare the clinical characteristics, outcomes, and etiology of pneumonia among children hospitalized with community-acquired pneumonia (CAP) with neurologic disorders, non-neurologic underlying conditions, and no underlying conditions.
  
  Study design
  
  Children <18 years old hospitalized with clinical and radiographic CAP were enrolled at 3 US children’s hospitals. Neurologic disorders included cerebral palsy, developmental delay, Down syndrome, epilepsy, non-Down syndrome chromosomal abnormalities, and spinal cord abnormalities. We compared the epidemiology, etiology, and clinical outcomes of CAP in children with neurologic disorders with those with non-neurologic underlying conditions, and those with no underlying conditions using bivariate, age-stratified, and multivariate logistic regression analyses.
  
  Results
  
  From January 2010–June 2012, 2358 children with radiographically confirmed CAP were enrolled; 280 (11.9%) had a neurologic disorder (52.1% of these individuals also had non-neurologic underlying conditions), 934 (39.6%) had non-neurologic underlying conditions only, and 1144 (48.5%) had no underlying conditions. Children with neurologic disorders were older and more likely to require intensive care unit (ICU) admission than children with non-neurologic underlying conditions and children with no underlying conditions; similar proportions were mechanically ventilated. In age-stratified analysis, children with neurologic disorders were less likely to have a pathogen detected than children with non-neurologic underlying conditions. In multivariate analysis, having a neurologic disorder was associated with ICU admission for children ≥2 years of age.
  
  Conclusions
  
  Children with neurologic disorders hospitalized with CAP were less likely to have a pathogen detected and more likely to be admitted to the ICU than children without neurologic disorders.
  
  
• Subjects:
  Adolescent Case-Control Studies Cerebral Palsy Child Child, Preschool Chromosome Aberrations Community-Acquired Infections Developmental Disabilities Down Syndrome Epilepsy Female Hospitalization Humans Intensive Care Units Length Of Stay Male Patient Admission Pneumonia Spinal Cord

  More +
• Source:
  J Pediatr. 173:188-195.e4.
• Pubmed ID:
  27017483
• Pubmed Central ID:
  PMC4897771
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States ; K23 AI104779/AI/NIAID NIH HHS/United States ; R03 HS022342/HS/AHRQ HHS/United States
• Place as Subject:
  Tennessee ; Utah
• Volume:
  173
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:c9b996d6c9783f9f39cf850025373394bbd7f64a154073ff6ebdd272f1ae0e48
• Download URL:
  https://stacks.cdc.gov/view/cdc/39848/cdc_39848_DS1.pdf
• File Type:
  [PDF - 199.62 KB ]