Varicella-Related Hospitalizations in the United States, 2000 –2006: The 1-Dose Varicella Vaccination Era

Details

• Alternative Title:
  Pediatrics
• Personal Author:
  Lopez, Adriana S. ; Zhang, John ; Brown, Cedric ; Bialek, Stephanie
• Description:
  OBJECTIVE ; To describe the effect of the mature 1-dose varicella vaccination program on varicella morbidity, we analyzed 2 national databases for varicella-related hospitalizations in the United States since implementation of the varicella vaccination program in 1995. ; PATIENTS AND METHODS ; Data from the National Hospital Discharge Survey and Nationwide Inpatient Sample were analyzed to describe trends in varicella-related hospitalizations during the 1-dose vaccination era (2000 –2006) compared with those in the prevaccination era (1988 –1995). Varicella-related hospitalizations were defined by using International Classification of Diseases, Ninth Revision codes. Results were extrapolated to represent national estimates. ; RESULTS ; Using National Hospital Discharge Survey data, 24 488 varicella-related hospitalizations were estimated to occur in the United States during the 1-dose vaccination era. The varicella-related hospitalization rate was 0.12 per 10 000 population during the 1-dose vaccination era versus 0.42 per 10 000 population in the prevaccination era (P < .01). During the 1-dose vaccination era, the estimated annual average number of varicella-related hospitalizations was significantly lower and decreased by ≥65% in all age groups compared with those in the prevaccination era (P < .001 in all age groups). The varicella-related hospitalization rate during the 1-dose vaccination era estimated from the Nationwide Inpatient Sample was 0.09 per 10 000 population. ; CONCLUSIONS ; Varicella-related hospitalization numbers and rates declined significantly during the 1-dose varicella vaccination era. Assuming declines in varicella-related hospitalizations are due, mainly, to the routine childhood varicella vaccination program, these data suggest that varicella vaccination prevented ~50 000 varicella-related hospitalizations in the United States from 2000 to 2006. Pediatrics 2011; 127:000
• Subjects:
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Chickenpox
  • Chickenpox Vaccine
  • Child
  • Child, Preschool
  • Databases, Factual
  • Drug Administration Schedule
  More +
• Source:
  Pediatrics. 127(2):238-245.
• Pubmed ID:
  21199857
• Pubmed Central ID:
  PMC4865884
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States
• Place as Subject:
  United States
• Volume:
  127
• Issue:
  2
• Download URL:
  https://stacks.cdc.gov/view/cdc/39456/cdc_39456_DS1.pdf
• File Type:
  [PDF - 1.36 MB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:1a14e2686f9c7de41c80b58491c1b729f6e04650782e19401d851375442a8b03