Evolution of Cryptococcal Antigen Testing: What is new?

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Evolution of Cryptococcal Antigen Testing: What is new?

Published Date:

Apr 12 2016

Source:

Curr Fungal Infect Rep. 10(2):62-67

Language:

English

[PDF-308.89 KB]

Details:

Alternative Title:

Curr Fungal Infect Rep

Personal Author:

Nalintya, Elizabeth ; Kiggundu, Reuben ; Meya, David ;

Description:

Over the last decade, an upsurge in both the frequency and severity of fungal infections due to the HIV/AIDS epidemic and the use of immunosuppressive therapy has occurred. Even diagnostic methods like culture and microscopy, which have low sensitivity and longer turn-around-times are not widely available, leading to delays in timely antifungal therapy and detrimental patient outcomes. The evolution of cryptococcal antigen (CrAg) testing to develop inexpensive and more sensitive methods to detect cryptococcal antigen is significant. These newer tests employ immunoassays as part of point-of-care platforms, which do not require complex laboratory infrastructure and they have the potential to detect early disease and reduce time to diagnosis of cryptococcal infection. Advocacy for widely available and efficacious life-saving antifungal treatment should be the only remaining challenge.

Subject:

[+]

Pubmed ID:

27158322

Pubmed Central ID:

PMC4858186

Document Type:

Journal Article

Funding:

U01 GH000517/GH/CGH CDC HHS/United States

Collection(s):

CDC Public Access

Main Document Checksum:

[+]

File Type:

Supporting Files:

nihms-777332.nxml

text/xml

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