Symptoms and Immune Markers in Plasmodium/Dengue Virus Co-infection Compared with Mono-infection with Either in Peru

Details

• Alternative Title:
  PLoS Negl Trop Dis
• Personal Author:
  Halsey, Eric S. ; Baldeviano, G. Christian ; Edgel, Kimberly A. ; Vilcarromero, Stalin ; Sihuincha, Moises ; Lescano, Andres G.
• Description:
  Background
  
  Malaria and dengue are two of the most common vector-borne diseases in the world, but co-infection is rarely described, and immunologic comparisons of co-infection with mono-infection are lacking.
  
  Methodology and Principal Findings
  
  We collected symptom histories and blood specimens from subjects in a febrile illness surveillance study conducted in Iquitos and Puerto Maldonado, Peru, between 2002–2011. Nineteen symptoms and 18 immune markers at presentation were compared among those with co-infection with Plasmodium/dengue virus (DENV), Plasmodium mono-infection, and DENV mono-infection. Seventeen subjects were identified as having Plasmodium/DENV co-infection and were retrospectively matched with 51 DENV mono-infected and 44 Plasmodium mono-infected subjects. Those with Plasmodium mono-infection had higher levels of IL-4, IL-6, IL-10, IL-12, IL-13, IL-17A, IFN-γ, and MIP1-α/CCL3 compared with DENV mono-infection or co-infection; those with Plasmodium mono-infection had more cough than those with DENV mono-infection. Subjects with DENV mono-infection had higher levels of TGF-β1 and more myalgia than those with Plasmodium mono-infection. No symptom was more common and no immune marker level was higher in the co-infected group, which had similar findings to the DENV mono-infected subjects.
  
  Conclusions/Significance
  
  Compared with mono-infection with either pathogen, Plasmodium/DENV co-infection was not associated with worse disease and resembled DENV mono-infection in both symptom frequency and immune marker level.
  
  
• Subjects:
  Adult Biomarkers Child Coinfection Cough/pathology Cytokines/blood Dengue Female Humans Malaria Male Middle Aged Myalgia Retrospective Studies Young Adult

  More +
• Source:
  PLoS Negl Trop Dis. 10(4).
• Pubmed ID:
  27128316
• Pubmed Central ID:
  PMC4851334
• Document Type:
  Journal Article
• Place as Subject:
  Peru
• Volume:
  10
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:227a6e500f97f61e945d1dac1f3c6cd77e96860017b889225bee8ca3331e9000
• Download URL:
  https://stacks.cdc.gov/view/cdc/39333/cdc_39333_DS1.pdf
• File Type:
  [PDF - 598.02 KB ]