Spontaneous emergence of overgrown molar teeth in a colony of Prairie voles (Microtus ochrogaster)

Jheon, Andrew H; Prochazkova, Michaela; Sherman, Michael; Manoli, Devanand S; Shah, Nirao M; Carbone, Lawrence; Klein, Ophir

doi:10.1038/ijos.2014.75

i

Spontaneous emergence of overgrown molar teeth in a colony of Prairie voles (Microtus ochrogaster)

Supporting Files

Mar 23 2015
By Jheon, Andrew H ; Prochazkova, Michaela ; Sherman, Michael ; ...

Details

Alternative Title:

Int J Oral Sci
Personal Author:

Jheon, Andrew H ; Prochazkova, Michaela ; Sherman, Michael ; Manoli, Devanand S ; Shah, Nirao M ; Carbone, Lawrence ; Klein, Ophir
Description:

Continuously growing incisors are common to all rodents, which include the Microtus genus of voles. However, unlike many rodents, voles also possess continuously growing molars. Here, we report spontaneous molar defects in a population of Prairie voles (Microtus ochrogaster). We identified bilateral protuberances on the ventral surface of the mandible in several voles in our colony. In some cases, the protuberances broke through the cortical bone. The mandibular molars became exposed and infected, and the maxillary molars entered the cranial vault. Visualisation upon soft tissue removal and microcomputed tomography (microCT) analyses confirmed that the protuberances were caused by the overgrowth of the apical ends of the molar teeth. We speculate that the unrestricted growth of the molars was due to the misregulation of the molar dental stem cell niche. Further study of this molar phenotype may yield additional insight into stem cell regulation and the evolution and development of continuously growing teeth.
Subjects:

Animals Arvicolinae Continuously Growing Teeth Female Humans Male Molar Molar Phenotype Mutation Original Article Pedigree Stem Cell Regulation Voles X-Ray Microtomography
Source:

Int J Oral Sci. 2015; 7(1):23-26.
Pubmed ID:

25634121
Pubmed Central ID:

PMC4817538
Document Type:

Journal Article
Funding:

DP1MH099900/DP/NCCDPHP CDC HHS/United States ; DP2-OD007191/OD/NIH HHS/United States ; R00 DE022059/DE/NIDCR NIH HHS/United States ; R00-DE022059/DE/NIDCR NIH HHS/United States ; R25 MH060482/MH/NIMH NIH HHS/United States ; S10RR026645/RR/NCRR NIH HHS/United States
Volume:

7
Issue:

1
Collection(s):

CDC Public Access
Main Document Checksum:

urn:sha256:b8932060c43c3fd42d4e430d9aec401c165fec7a2fbbceff19572280f06338c4
Download URL:

https://stacks.cdc.gov/view/cdc/39241/cdc_39241_DS1.pdf
File Type:

[PDF - 3.99 MB ]

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