Details:

Alternative Title:
PLoS One
Publisher's site:
http://dx.doi.org/10.1371/journal.pone.0153728
Personal Author:
Yuen, Courtney M. ; Kammerer, J. Steve ; Marks, Kala ; Navin, Thomas R. ; France, Anne Marie ;
Yuen, Courtney M. ; Kammerer, J. Steve ; Marks, Kala ; Navin, Thomas R. ; France, Anne Marie ; Less -
Description:
Tuberculosis is an infectious disease that may result from recent transmission or from an infection acquired many years in the past; there is no diagnostic test to distinguish the two causes. Cases resulting from recent transmission are particularly concerning from a public health standpoint. To describe recent tuberculosis transmission in the United States, we used a field-validated plausible source-case method to estimate cases likely resulting from recent transmission during January 2011-September 2014. We classified cases as resulting from either limited or extensive recent transmission based on transmission cluster size. We used logistic regression to analyze patient characteristics associated with recent transmission. Of 26,586 genotyped cases, 14% were attributable to recent transmission, 39% of which were attributable to extensive recent transmission. The burden of cases attributed to recent transmission was geographically heterogeneous and poorly predicted by tuberculosis incidence. Extensive recent transmission was positively associated with American Indian/Alaska Native (adjusted prevalence ratio [aPR] = 3.6 (95% confidence interval [CI] 2.9-4.4), Native Hawaiian/Pacific Islander (aPR = 3.2, 95% CI 2.3-4.5), and black (aPR = 3.0, 95% CI 2.6-3.5) race, and homelessness (aPR = 2.3, 95% CI 2.0-2.5). Extensive recent transmission was negatively associated with foreign birth (aPR = 0.2, 95% CI 0.2-0.2). Tuberculosis control efforts should prioritize reducing transmission among higher-risk populations.
Subject:
[+]
Adolescent
Adult
Aged
Bacterial Typing Techniques
Blacks
Child
Child, Preschool
Communicable Disease Control
Emigration And Immigration
Female
Genotype
Homeless Persons
Humans
Indians, North American
Infant
Infant, Newborn
Male
Middle Aged
Mycobacterium Tuberculosis
Prevalence
Risk Factors
Tuberculosis
Tuberculosis/ethnology
Young Adult

Source:
PLoS One. 11(4). ;
Pubmed ID:
27082644
Pubmed Central ID:
PMC4833321
Document Type:
Journal Article ;
Place as Subject:
United States ;
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:03b3c71a994505fd8ef2f7ed7ce908aa204245889976f1cbd6684b93217fd13b
File Type:

Supporting Files

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