Impact of Immunosuppression on Recall Immune Responses to Influenza Vaccination in Stable Renal Transplant Recipients

Details

• Alternative Title:
  Transplantation
• Personal Author:
  Cowan, Michelle ; Chon, W. James ; Desai, Amishi ; Andrews, Sarah ; Bai, Yaohui ; Veguilla, Vic ; Katz, Jacqueline M. ; Josephson, Michelle A. ; Wilson, Patrick C. ; Sciammas, Roger ; Chong, Anita S.
• Description:
  Background
  
  The recommendation by the American Society of Transplantation for annual trivalent inactivated influenza vaccination greater than 3 to 6 months post-kidney transplantation provides a unique opportunity to test the in vivo impact of immunosuppression on recall T- and B-cell responses to influenza vaccination.
  
  Methods
  
  This study took advantage of recent breakthroughs in the single-cell quantification of human peripheral blood B-cell responses to prospectively evaluate both B- and T-cell responses to the seasonal (2010 and 2011) influenza vaccine in 23 stable renal transplant recipients and 22 healthy controls.
  
  Results and Conclusion
  
  The results demonstrate that the early B-cell response to influenza vaccination, quantified by the frequency of influenza-specific antibody-secreting cells (ASC) in peripheral blood, was significantly reduced in stable transplant recipients compared to healthy controls. The magnitude of the seroresponse and the rate of sero-conversion were also blunted. The influenza-specific interferon-gamma (IFNγ) T-cell response was significantly reduced in transplant recipients; however, there was no correlation between the magnitude of the influenza-specific IgG ASC and IFNγ responses. The induction of memory T- and B-cell responses to influenza vaccination supports the recommendation to vaccinate while the blunted responses demonstrate the efficacy of immunosuppression in controlling memory responses individual transplant recipients.
  
  
• Subjects:
  Adult Antibodies, Viral Article B-Lymphocytes Female Graft Rejection Humans Immunologic Memory Immunosuppressive Agents Influenza Vaccines Kidney Transplantation Male Middle Aged Neutralization Tests Prospective Studies T-Lymphocytes

  More +
• Source:
  Transplantation. 97(8):846-853
• Pubmed ID:
  24366008
• Pubmed Central ID:
  PMC4843769
• Document Type:
  Journal Article
• Funding:
  R01AI083452/AI/NIAID NIH HHS/United States ; P01AI097113/AI/NIAID NIH HHS/United States ; CC999999/Intramural CDC HHS/United States ; R01 AI072630/AI/NIAID NIH HHS/United States ; R01AI072630/AI/NIAID NIH HHS/United States ; P01 AI097113/AI/NIAID NIH HHS/United States ; R01 AI083452/AI/NIAID NIH HHS/United States
• Volume:
  97
• Issue:
  8
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:29ecee4ab92691f7f5c60454078a7c2b22acfcc5674fe20f009322588ba3733f
• Download URL:
  https://stacks.cdc.gov/view/cdc/39092/cdc_39092_DS1.pdf
• File Type:
  [PDF - 870.45 KB ]