Concentrations of the Sunscreen Agent Benzophenone-3 in Residents of the United States: National Health and Nutrition Examination Survey 2003–2004
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Concentrations of the Sunscreen Agent Benzophenone-3 in Residents of the United States: National Health and Nutrition Examination Survey 2003–2004

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  • English
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    Details:

    • Alternative Title:
      Environ Health Perspect
    • Personal Author:
    • Description:
      Background

      The capability of benzophenone-3 (BP-3) to absorb and dissipate ultraviolet radiation facilitates its use as a sunscreen agent. BP-3 has other uses in many consumer products (e.g., as fragrance and flavor enhancer, photoinitiator, ultraviolet curing agent, polymerization inhibitor).

      Objectives

      Our goal was to assess exposure to BP-3 in a representative sample of the U.S. general population ≥ 6 years of age.

      Methods

      Using automated solid-phase extraction coupled to high-performance liquid chromatography–tandem mass spectrometry, we analyzed 2,517 urine samples collected as part of the 2003–2004 National Health and Nutrition Examination Survey.

      Results

      We detected BP-3 in 96.8% of the samples. The geometric mean and 95th percentile concentrations were 22.9 μg/L (22.2 μg/g creatinine) and 1,040 μg/L (1,070 μg/g creatinine), respectively. Least-square geometric mean (LSGM) concentrations were significantly higher (p ≤ 0.04) for females than for males, regardless of age. LSGM concentrations were significantly higher for non-Hispanic whites than for non-Hispanic blacks (p ≤ 0.01), regardless of age. Females were more likely than males [adjusted odds ratio (OR) = 3.5; 95% confidence interval (95% CI), 1.9–6.5], and non-Hispanic whites were more likely than non-Hispanic blacks (adjusted OR = 6.8; 95% CI, 2.9–16.2) to have concentrations above the 95th percentile.

      Conclusions

      Exposure to BP-3 was prevalent in the general U.S. population during 2003–2004. Differences by sex and race/ethnicity probably reflect differences in use of personal care products containing BP-3.

    • Subject:
    • Source:
      Environ Health Perspect. 2008; 116(7):893-897.
    • Document Type:
      Journal Article
    • Place as Subject:
      United States
    • Collection(s):
      CDC Public Access
    • Main Document Checksum:
    • File Type:

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