Systematic review of the birth prevalence of congenital cytomegalovirus infection in developing countries

Lanzieri, Tatiana M.; Dollard, Sheila C.; Bialek, Stephanie R.; Grosse, Scott D.

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Systematic review of the birth prevalence of congenital cytomegalovirus infection in developing countries

Published Date:

Mar 12 2014

Source:

Int J Infect Dis. 22:44-48.

[PDF-68.30 KB]

Details:

Alternative Title:

Int J Infect Dis

Personal Author:

Lanzieri, Tatiana M. ; Dollard, Sheila C. ; Bialek, Stephanie R. ; Grosse, Scott D. ;

Description:

Background

Congenital cytomegalovirus (CMV) infection is the leading infectious cause of congenital hearing loss and neurodevelopmental disability in developed countries. Information on congenital CMV infection in developing countries appears to be lacking.

Methods

We conducted a systematic literature review to identify studies from developing countries with population-based samples of at least 300 infants that used laboratory methods established as reliable for the diagnosis of congenital CMV infection.

Results

Most studies were excluded due to biased samples or inadequate diagnostic methods; consequently the search identified just 11 studies that were from Africa, Asia, and Latin America. The number of newborns tested ranged from 317 to 12 195. Maternal CMV seroprevalence ranged from 84% to 100%. CMV birth prevalence varied from 0.6% to 6.1%. CMV-associated impairments were not documented in most studies.

Conclusions

Birth prevalence ranges were higher than for Europe and North America, as expected based on the higher maternal CMV seroprevalence. With very limited data available on sequelae, the disease burden of congenital CMV in developing countries remains largely unknown at this time.

Subject:

[+]

Pubmed ID:

24631522

Pubmed Central ID:

PMC4829484

Document Type:

Journal Article

Funding:

CC999999/Intramural CDC HHS/United States

Place as Subject:

Latin America

Collection(s):

CDC Public Access

Main Document Checksum:

[+]

Supporting Files:

nihms775032.nxml

text/xml

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