Details:

Alternative Title:
Int J Infect Dis
Personal Author:
Lanzieri, Tatiana M. ; Dollard, Sheila C. ; Bialek, Stephanie R. ; Grosse, Scott D.
Lanzieri, Tatiana M. ; Dollard, Sheila C. ; Bialek, Stephanie R. ; Grosse, Scott D. Less -
Description:
Background

Congenital cytomegalovirus (CMV) infection is the leading infectious cause of congenital hearing loss and neurodevelopmental disability in developed countries. Information on congenital CMV infection in developing countries appears to be lacking.

Methods

We conducted a systematic literature review to identify studies from developing countries with population-based samples of at least 300 infants that used laboratory methods established as reliable for the diagnosis of congenital CMV infection.

Results

Most studies were excluded due to biased samples or inadequate diagnostic methods; consequently the search identified just 11 studies that were from Africa, Asia, and Latin America. The number of newborns tested ranged from 317 to 12 195. Maternal CMV seroprevalence ranged from 84% to 100%. CMV birth prevalence varied from 0.6% to 6.1%. CMV-associated impairments were not documented in most studies.

Conclusions

Birth prevalence ranges were higher than for Europe and North America, as expected based on the higher maternal CMV seroprevalence. With very limited data available on sequelae, the disease burden of congenital CMV in developing countries remains largely unknown at this time.


Subject:
[+]
Article
Cytomegalovirus Infections
Developing Countries
Female
Humans
Infant
Infant, Newborn
Infectious Disease Transmission, Vertical
Pregnancy

Source:
Int J Infect Dis. 22:44-48.
Pubmed ID:
24631522
Pubmed Central ID:
PMC4829484
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Place as Subject:
Latin America
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:240381b6a6c2ad208a9bfd6277a4dfa1788ee40bcaf27d8b7517d02c0e333994
File Type:

Supporting Files

• nihms775032.nxml

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