Development of a Standard Reference Material for Metabolomics Research

Phinney, Karen W.; Ballihaut, Guillaume; Bedner, Mary; Benford, Brandi S.; Camara, Johanna E.; Christopher, Steven J.; Davis, W. Clay; Dodder, Nathan G.; Eppe, Gauthier; Lang, Brian E.; Long, Stephen E.; Lowenthal, Mark S.; McGaw, Elizabeth A.; Murphy, Karen E.; Nelson, Bryant C.; Prendergast, Jocelyn L.; Reiner, Jessica L.; Rimmer, Catherine A.; Sander, Lane C.; Schantz, Michele M.; Sharpless, Katherine E.; Sniegoski, Lorna T.; Tai, Susan S.-C.; Thomas, Jeanice B.; Vetter, Thomas W.; Welch, Michael J.; Wise, Stephen A.; Wood, Laura J.; Guthrie, William F.; Hagwood, Charles R.; Leigh, Stefan D.; Yen, James H.; Zhang, Nien-Fan; Chaudhary-Webb, Madhu; Chen, Huiping; Fazili, Zia; LaVoie, Donna J.; McCoy, Leslie F.; Momin, Shahzad S.; Paladugula, Neelima; Pendergrast, Elizabeth C.; Pfeiffer, Christine M.; Powers, Carissa D.; Rabinowitz, Daniel; Rybak, Michael E.; Schleicher, Rosemary L.; Toombs, Bridgette M. H.; Xu, Mary; Zhang, Mindy; Castle, Arthur L.

doi:10.1021/ac402689t

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Development of a Standard Reference Material for Metabolomics Research

Published Date:

Dec 03 2013

Publisher's site:

http://dx.doi.org/10.1021/ac402689t New Site Icon

Source:

Anal Chem. 85(24):11732-11738.

[PDF - 451.87 KB]

Details:

Personal Authors:

Phinney, Karen W. ; Ballihaut, Guillaume ; Bedner, Mary ; Benford, Brandi S. ; Camara, Johanna E. ; ... More ▼

Keywords:

[+]

Pubmed ID:

24187941

Pubmed Central ID:

PMC4823010

Description:

The National Institute of Standards and Technology (NIST), in collaboration with the National Institutes of Health (NIH), has developed a Standard Reference Material (SRM) to support technology development in metabolomics research. SRM 1950 Metabolites in Human Plasma is intended to have metabolite concentrations that are representative of those found in adult human plasma. The plasma used in the preparation of SRM 1950 was collected from both male and female donors, and donor ethnicity targets were selected based upon the ethnic makeup of the U.S. population. Metabolomics research is diverse in terms of both instrumentation and scientific goals. This SRM was designed to apply broadly to the field, not toward specific applications. Therefore, concentrations of approximately 100 analytes, including amino acids, fatty acids, trace elements, vitamins, hormones, selenoproteins, clinical markers, and perfluorinated compounds (PFCs), were determined. Value assignment measurements were performed by NIST and the Centers for Disease Control and Prevention (CDC). SRM 1950 is the first reference material developed specifically for metabolomics research.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

CC999999/Intramural CDC HHS/United States

Supporting Files:

NIHMS768679-supplement-Supporting_materila.pdf	application/pdf
nihms768679.nxml	application/octet-stream
nihms768679f1.gif	image/gif
nihms768679f1.jpg	image/jpeg
nihms768679u1.jpg	image/jpeg

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