Details:

Alternative Title:
J Nutr
Personal Author:
Vesper, Hubert W. ; Sternberg, Maya R. ; Frame, Tunde ; Pfeiffer, Christine M.
Vesper, Hubert W. ; Sternberg, Maya R. ; Frame, Tunde ; Pfeiffer, Christine M. Less -
Description:
Hemoglobin adducts of acrylamide (HbAA) and glycidamide (HbGA) have been measured as biomarkers of acrylamide exposure and metabolism in a nationally representative sample of the U.S. population in the NHANES 2003-2004. We assessed the association of sociodemographic (age, sex, race-ethnicity, education, and income) and lifestyle (smoking, alcohol consumption, BMI, physical activity, and dietary supplement use) variables with these biomarkers in U.S. adults (aged ≥ 20 y). We used bivariate and multiple regression models and assessed the magnitude of an estimated change in biomarker concentration with change in a covariable for 2 biomarkers of acrylamide exposure. Smoking was strongly and significantly correlated with HbAA and HbGA concentrations (rs = 0.51 and 0.42, respectively), with biomarker concentrations being 126 and 101% higher in smokers compared with nonsmokers after adjusting for sociodemographic and lifestyle covariates. Age was moderately and significantly correlated with both biomarkers (rs = -0.21 and -0.22, respectively). BMI (rs = -0.11) and alcohol consumption (rs = 0.13) were weakly yet significantly correlated with HbAA concentrations only. The estimated percentage change in biomarker concentration was ≤ 20% for all variables other than smoking after adjusting for sociodemographic and lifestyle covariates. Using multiple regression models, the sociodemographic variables explained 9 and 7% whereas the sociodemographic and lifestyle variables together explained 46 and 25% of the variability in HbAA and HbGA, respectively, showing the importance of considering and adequately controlling for these variables in future studies. Our findings will be useful in the design and analysis of future studies that assess and evaluate exposure to acrylamide and its metabolism to glycidamide.
Subject:
[+]
Acrylamide
Adult
Age Factors
Alcohol Drinking
Biomarkers
Environmental Exposure
Epoxy Compounds
Female
Hemoglobins
Humans
Life Style
Liver
Male
Middle Aged
Nutrition Surveys
Regression Analysis
Sex Factors
Smoking
Socioeconomic Factors

Source:
J Nutr. 143(6):995S-1000S.
Pubmed ID:
23596166
Pubmed Central ID:
PMC4822994
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Name as Subject:
National Health and Nutrition Examination Survey (U.S.)
Place as Subject:
United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:0ccbf40d74247742d43a4926485de6cffc1b434caab9a0f791f777219d3a6061
File Type:

Supporting Files

• 	NIHMS768647-supplement-Supplemental_materials.pdf	pdf
  	nihms768647.nxml	xml
  	nihms768647f1.gif	gif
  	nihms768647f1.jpg	jpeg

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