Prevalence and Morbidity of Primary Immunodeficiency Diseases, United States 2001–2007

Kobrynski, Lisa; Powell, Rachel Waltenburg; Bowen, Scott

doi:10.1007/s10875-014-0102-8

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Prevalence and Morbidity of Primary Immunodeficiency Diseases, United States 2001–2007

Published Date:

Sep 26 2014

Publisher's site:

http://dx.doi.org/10.1007/s10875-014-0102-8 New Site Icon

Source:

J Clin Immunol. 34(8):954-961.

Language:

English

[PDF-682.71 KB]

Details:

Alternative Title:

J Clin Immunol

Personal Author:

Kobrynski, Lisa ; Powell, Rachel Waltenburg ; Bowen, Scott ;

Description:

Purpose

Few studies have estimated population prevalence and morbidity of primary immunodeficiency diseases (PIDD). We used administrative healthcare databases to estimate the prevalence of PIDD diagnoses in the United States from 2001 to 2007.

Methods

MarketScan databases compile claims from commercial health insurance plans and Medicaid, recording individual diagnoses for outpatient encounters and hospital stays. We used a cross sectional survey to estimate prevalence of PIDD using related ICD-9 codes (279.0, 279.1, 279.2, 279.8, 279.9, 288.1 and 288.2). Persons with secondary immunodeficiency diagnoses were excluded from analysis.

Results

Between 2001 and 2007, prevalence of any PIDD diagnosis increased from 38.9 to 50.5 per 100,000 among privately insured and from 29.1 to 41.1 per 100,000 among publicly insured persons. B cell defects predominated. Prevalence was more than twice as high among Whites as among Blacks or Hispanics.

Conclusion

In this large database, we found a higher prevalence of diagnosed PIDD than has been reported previously from registries. Increased awareness may have contributed to the increasing prevalence.

Subject:

[+]

Pubmed ID:

25257253

Pubmed Central ID:

PMC4820073

Document Type:

Journal Article

Funding:

CC999999/Intramural CDC HHS/United States

Place as Subject:

United States

Collection(s):

CDC Public Access

Main Document Checksum:

[+]

Supporting Files:

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	NIHMS746860-supplement-Supplemental_Table-E-1.pdf	application/pdf

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