25644379

PMC4816651

DP1 HL123271/HL/NHLBI NIH HHS/United States
DP1-HL123271/DP/NCCDPHP CDC HHS/United States
R01-HL103428/HL/NHLBI NIH HHS/United States

CDC Public Access

Using a three-dimensional electromechanical model of the canine ventricles with dyssynchronous heart failure, we investigated the relationship between severity of valve regurgitation and ventricular mechanical responses. The results demonstrated that end-systolic tension in the septum and left ventricular free wall was significantly lower under the condition of mitral regurgitation (MR) than under aortic regurgitation (AR). Stroke work in AR was higher than that in MR. On the other hand, the difference in stroke volume between the two conditions was not significant, indicating that AR may cause worse pumping efficiency than MR in terms of consumed energy and performed work.