Details:

Alternative Title:
J Physiol Sci
Publisher's site:
http://dx.doi.org/10.1007/s12576-014-0353-4
Personal Author:
Lim, Ki Moo ; Hong, Seung-Bae ; Lee, Byong Kwon ; Shim, Eun Bo ; Trayanova, Natalia
Lim, Ki Moo ; Hong, Seung-Bae ; Lee, Byong Kwon ; Shim, Eun Bo ; Trayanova, Natalia Less -
Description:
Using a three-dimensional electromechanical model of the canine ventricles with dyssynchronous heart failure, we investigated the relationship between severity of valve regurgitation and ventricular mechanical responses. The results demonstrated that end-systolic tension in the septum and left ventricular free wall was significantly lower under the condition of mitral regurgitation (MR) than under aortic regurgitation (AR). Stroke work in AR was higher than that in MR. On the other hand, the difference in stroke volume between the two conditions was not significant, indicating that AR may cause worse pumping efficiency than MR in terms of consumed energy and performed work.
Subjects:
[+]
Animals Aortic Valve Insufficiency Article Cardiac Electromechanical Model Dogs Heart Failure Heart Ventricles Mitral Valve Insufficiency Models, Biological Regurgitant Volume Stroke Volume Stroke Work Valve Regurgitation Ventricular Function, Left
Source:
J Physiol Sci. 65(2):159-164.
Pubmed ID:
25644379
Pubmed Central ID:
PMC4816651
Document Type:
Journal Article
Funding:
DP1 HL123271/HL/NHLBI NIH HHS/United States ; DP1-HL123271/DP/NCCDPHP CDC HHS/United States ; R01-HL103428/HL/NHLBI NIH HHS/United States
DP1 HL123271/HL/NHLBI NIH HHS/United States ; DP1-HL123271/DP/NCCDPHP CDC HHS/United States ; R01-HL103428/HL/NHLBI NIH HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:49c7948765d3270c47903c1e0eb33a4b3ba697123c1a5a565b1419dc62b9c0dc
Download URL:
https://stacks.cdc.gov/view/cdc/38761/cdc_38761_DS1.pdf
File Type:

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