Computational analysis of the effect of valvular regurgitation on ventricular mechanics using a 3D electromechanics model

Details

• Alternative Title:
  J Physiol Sci
• Personal Author:
  Lim, Ki Moo ; Hong, Seung-Bae ; Lee, Byong Kwon ; Shim, Eun Bo ; Trayanova, Natalia
• Description:
  Using a three-dimensional electromechanical model of the canine ventricles with dyssynchronous heart failure, we investigated the relationship between severity of valve regurgitation and ventricular mechanical responses. The results demonstrated that end-systolic tension in the septum and left ventricular free wall was significantly lower under the condition of mitral regurgitation (MR) than under aortic regurgitation (AR). Stroke work in AR was higher than that in MR. On the other hand, the difference in stroke volume between the two conditions was not significant, indicating that AR may cause worse pumping efficiency than MR in terms of consumed energy and performed work.
• Subjects:
  Animals Aortic Valve Insufficiency Article Cardiac Electromechanical Model Dogs Heart Failure Heart Ventricles Mitral Valve Insufficiency Models, Biological Regurgitant Volume Stroke Volume Stroke Work Valve Regurgitation Ventricular Function, Left

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• Source:
  J Physiol Sci. 65(2):159-164.
• Pubmed ID:
  25644379
• Pubmed Central ID:
  PMC4816651
• Document Type:
  Journal Article
• Funding:
  DP1 HL123271/HL/NHLBI NIH HHS/United States ; DP1-HL123271/DP/NCCDPHP CDC HHS/United States ; R01-HL103428/HL/NHLBI NIH HHS/United States
• Volume:
  65
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:49c7948765d3270c47903c1e0eb33a4b3ba697123c1a5a565b1419dc62b9c0dc
• Download URL:
  https://stacks.cdc.gov/view/cdc/38761/cdc_38761_DS1.pdf
• File Type:
  [PDF - 1.31 MB ]