Details:

Alternative Title:
J Nutr
Personal Author:
Pfeiffer, Christine M. ; Sternberg, Maya R. ; Caldwell, Kathleen L. ; Pan, Yi
Pfeiffer, Christine M. ; Sternberg, Maya R. ; Caldwell, Kathleen L. ; Pan, Yi Less -
Description:
The NHANES 2003-2006 has assessed iron and iodine status, 2 trace element nutrients of continued public health interest, in the U.S. population. We investigated associations of sociodemographic (age, sex, race-ethnicity, education, income) and lifestyle (smoking, alcohol consumption, BMI, physical activity, dietary supplement use) variables with the iron status indicators serum ferritin, soluble transferrin receptor (sTfR), and body iron in women aged 20-49 y (n = 2539, 2513, and 2509, respectively) and with urine iodine, a biomarker of iodine intake, in adults aged ≥ 20 y (n = 3066). Significant correlations between the study variables and biomarkers were weak (|r| ≤ 0.24). Urine creatinine (uCr) was moderately significantly correlated with urine iodine (r = 0.52). The individual variables explained ≤ 5% of the variability in biomarker concentrations in bivariate analysis. In multiple regression models, sociodemographic and lifestyle variables together explained 4-13% of the variability in iron indicators and 41% of the variability in urine iodine (uCr in the model). The adjusted estimated body iron was ≈ 1 unit (mg/kg) lower in non-Hispanic black vs. non-Hispanic white women and ≈ 1 unit higher in women who smoked vs. those who did not and in women consuming 1 vs. 0 alcoholic drinks/d. The adjusted estimated urine iodine concentration (uCr in the model) was 34% lower in non-Hispanic blacks vs. non-Hispanic whites, 22% higher in supplement users vs. nonusers, and 11% higher with every 10-y increase in age. In summary, after adjusting for sociodemographic and lifestyle variables (and uCr in the iodine model), race-ethnicity retained a strong association with sTfR, body iron, and urine iodine; smoking and alcohol consumption with iron biomarkers; and supplement use and age with urine iodine.
Subjects:
[+]
Adult Alcohol Drinking Biomarkers Black Or African American Creatinine Ethnicity Female Ferritins Humans Iodine Iron Life Style Male Middle Aged Nutritional Status Nutrition Surveys Racial Groups Receptors, Transferrin Smoking Socioeconomic Factors White
Source:
J Nutr. 143(6):977S-985S.
Pubmed ID:
23596169
Pubmed Central ID:
PMC4811330
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:181eb63ed409ec6b68ce6ead3b8f75fd58d7532353b69c4e01c2000e7dfbf8c4
Download URL:
https://stacks.cdc.gov/view/cdc/38742/cdc_38742_DS1.pdf
File Type:

Supporting Files

• 	NIHMS768642-supplement-Supplemental_materials.pdf	pdf
  	nihms768642.nxml	xml

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