during Epidemic, United Kingdom, 2005–2010

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Petrovska, Liljana ; Mather, Alison E. ; AbuOun, Manal ; Branchu, Priscilla ; Harris, Simon R. ; Connor, Thomas ; Hopkins, K.L. ; Underwood, A. ; Lettini, Antonia A. ; Page, Andrew ; Bagnall, Mary ; Wain, John ; Parkhill, Julian ; Dougan, Gordon ; Davies, Robert ; Kingsley, Robert A.
• Description:
  Microevolution associated with emergence and expansion of new epidemic clones of bacterial pathogens holds the key to epidemiologic success. To determine microevolution associated with monophasic Salmonella Typhimurium during an epidemic, we performed comparative whole-genome sequencing and phylogenomic analysis of isolates from the United Kingdom and Europe during 2005-2012. These isolates formed a single clade distinct from recent monophasic epidemic clones previously described from North America and Spain. The UK monophasic epidemic clones showed a novel genomic island encoding resistance to heavy metals and a composite transposon encoding antimicrobial drug resistance genes not present in other Salmonella Typhimurium isolates, which may have contributed to epidemiologic success. A remarkable amount of genotypic variation accumulated during clonal expansion that occurred during the epidemic, including multiple independent acquisitions of a novel prophage carrying the sopE gene and multiple deletion events affecting the phase II flagellin locus. This high level of microevolution may affect antigenicity, pathogenicity, and transmission.
• Subjects:
  Anti-Bacterial Agents Bacterial Proteins Bacterial Typing Techniques Clonal Evolution Clone Cells Disease Outbreaks DNA Transposable Elements Drug Resistance, Multiple, Bacterial Epidemiological Monitoring Flagellin Gene Expression Regulation, Bacterial Genetic Variation Genomic Islands Humans Phylogeny Prophages Salmonella Infections Salmonella Typhimurium

  More +
• Source:
  Emerg Infect Dis. 22(4):617-624.
• Pubmed ID:
  26982594
• Pubmed Central ID:
  PMC4806966
• Document Type:
  Journal Article
• Place as Subject:
  Europe ; United Kingdom
• Location:
  Europe
• Volume:
  22
• Issue:
  4
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:6408b25d0954b2637130401968ce6137d7d8597dc6d1bfc2fb29a0ee2d33a9b4
• Download URL:
  https://stacks.cdc.gov/view/cdc/38703/cdc_38703_DS1.pdf
• File Type:
  [PDF - 685.84 KB ]