Co-Feeding Transmission of the Ehrlichia muris–Like Agent to Mice (Mus musculus)
Published Date:Jan 29 2016
Source:Vector Borne Zoonotic Dis. 16(3):145-150.
Disease Models, Animal
Ehrlichia Muris–like Agent (EMLA)
Mice, Inbred C57BL
Specific Pathogen-Free Organisms
Pubmed Central ID:PMC4809518
Funding:CC999999/Intramural CDC HHS/United States
Description:The Ehrlichia muris-like agent (EMLA) is a newly recognized human pathogen found in Wisconsin and Minnesota. Ecological investigations have implicated both the blacklegged tick, Ixodes scapularis, and the white-footed mouse, Peromyscus leucopus, as playing roles in the maintenance of EMLA in nature. The work presented here shows that I. scapularis is an efficient vector of EMLA in a laboratory mouse model, but that Dermacentor variabilis, another frequent human biting tick found in EMLA endemic areas, is not. Additionally, I. scapularis larvae are able to acquire EMLA through co-feeding with infected nymphs. As EMLA only persists in mouse blood for a relatively short period of time, co-feeding transmission may play an important role in the maintenance of EMLA in ticks, and subsequently may play a role in limiting the geographic distribution of this pathogen in areas where co-feeding of larvae and nymphs is less common.
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