Co-Feeding Transmission of the Ehrlichia muris–Like Agent to Mice (Mus musculus)

Details

• Alternative Title:
  Vector Borne Zoonotic Dis
• Personal Author:
  Karpathy, Sandor E. ; Allerdice, Michelle E.J. ; Sheth, Mili ; Dasch, Gregory A. ; Levin, Michael L.
• Description:
  The Ehrlichia muris-like agent (EMLA) is a newly recognized human pathogen found in Wisconsin and Minnesota. Ecological investigations have implicated both the blacklegged tick, Ixodes scapularis, and the white-footed mouse, Peromyscus leucopus, as playing roles in the maintenance of EMLA in nature. The work presented here shows that I. scapularis is an efficient vector of EMLA in a laboratory mouse model, but that Dermacentor variabilis, another frequent human biting tick found in EMLA endemic areas, is not. Additionally, I. scapularis larvae are able to acquire EMLA through co-feeding with infected nymphs. As EMLA only persists in mouse blood for a relatively short period of time, co-feeding transmission may play an important role in the maintenance of EMLA in ticks, and subsequently may play a role in limiting the geographic distribution of this pathogen in areas where co-feeding of larvae and nymphs is less common.
• Subjects:
  Animals Arachnid Vectors Disease Models, Animal Disease Reservoirs Ehrlichia Ehrlichiosis Female Humans Ixodes Larva Mice Mice, Inbred C57BL Nymph Peromyscus Rabbits Specific Pathogen-Free Organisms Tick Infestations

  More +
• Source:
  Vector Borne Zoonotic Dis. 16(3):145-150.
• Pubmed ID:
  26824725
• Pubmed Central ID:
  PMC4809518
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States
• Place as Subject:
  Minnesota ; Wisconsin
• Volume:
  16
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:80ab9416b1972813afde834cb402325cabc8585113ab7ca7662e54f17615140e
• Download URL:
  https://stacks.cdc.gov/view/cdc/38657/cdc_38657_DS1.pdf
• File Type:
  [PDF - 297.50 KB ]