Co-Feeding Transmission of the Ehrlichia muris–Like Agent to Mice (Mus musculus)

Karpathy, Sandor E.; Allerdice, Michelle E.J.; Sheth, Mili; Dasch, Gregory A.; Levin, Michael L.

doi:10.1089/vbz.2015.1878

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Co-Feeding Transmission of the Ehrlichia muris–Like Agent to Mice (Mus musculus)

Published Date:

Jan 29 2016

Publisher's site:

http://dx.doi.org/10.1089/vbz.2015.1878 New Site Icon

Source:

Vector Borne Zoonotic Dis. 16(3):145-150.

[PDF-297.50 KB]

Details:

Personal Authors:

Karpathy, Sandor E. ; Allerdice, Michelle E.J. ; Sheth, Mili ; Dasch, Gregory A. ; Levin, Michael L. ;

Keywords:

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Pubmed ID:

26824725

Pubmed Central ID:

PMC4809518

Description:

The Ehrlichia muris-like agent (EMLA) is a newly recognized human pathogen found in Wisconsin and Minnesota. Ecological investigations have implicated both the blacklegged tick, Ixodes scapularis, and the white-footed mouse, Peromyscus leucopus, as playing roles in the maintenance of EMLA in nature. The work presented here shows that I. scapularis is an efficient vector of EMLA in a laboratory mouse model, but that Dermacentor variabilis, another frequent human biting tick found in EMLA endemic areas, is not. Additionally, I. scapularis larvae are able to acquire EMLA through co-feeding with infected nymphs. As EMLA only persists in mouse blood for a relatively short period of time, co-feeding transmission may play an important role in the maintenance of EMLA in ticks, and subsequently may play a role in limiting the geographic distribution of this pathogen in areas where co-feeding of larvae and nymphs is less common.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

CC999999/Intramural CDC HHS/United States

Main Document Checksum:

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Supporting Files:

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