Details:

Alternative Title:
Environ Health Perspect
Personal Author:
Huhn, Gregory D. ; Austin, Connie ; Carr, Mark ; Heyer, Diana ; Boudreau, Pam ; ... More +
Huhn, Gregory D. ; Austin, Connie ; Carr, Mark ; Heyer, Diana ; Boudreau, Pam ; Gilbert, Glynnis ; Eimen, Terry ; Lindsley, Mark D. ; Cali, Salvatore ; Conover, Craig S. ; Dworkin, Mark S. Less -
Description:
The objective of this study was to determine the etiology and risk factors for acute histoplasmosis in two outbreaks in Illinois among laborers at a landfill in 2001 and at a bridge reconstruction site in 2003.|We performed environmental investigations during both outbreaks and also performed an analytic cohort study among bridge workers.|Workers at the landfill during May 2001 and those at the bridge site during August 2003 participated in the study. At the landfill, workers moved topsoil from an area that previously housed a barn; at the bridge, workers observed bat guano on bridge beams.|We defined a case by positive immunodiffusion serology, a > or = 4-fold titer rise in complement fixation between acute and convalescent sera, or positive urinary Histoplasma capsulatum (HC) antigen. Relative risks (RR) for disease among bridge workers were calculated using bivariate analysis.|Eight of 11 landfill workers (73%) and 6 of 12 bridge workers (50%) were laboratory-confirmed histoplasmosis cases. Three bridge workers had positive urinary HC antigen. At the bridge, seeing or having contact with bats [RR = 7.0; 95% confidence interval (CI), 1.1-43.0], jack-hammering (RR = 4.0; 95% CI, 1.2-13.3), and waste disposal (RR = 4.0; 95% CI, 1.2-13.3) were the most significant job-related risk factors for acquiring histoplasmosis.|Workers performing activities that aerosolized topsoil and dust were at increased risk for acquiring histoplasmosis. Relevance to professional and clinical practice: Employees should wear personal protective equipment and use dust-suppression techniques when working in areas potentially contaminated with bird or bat droppings. Urinary HC antigen testing was important in rapidly identifying disease in the 2003 outbreak.
Subjects:
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Adult Aerosols Antigens, Fungal Disease Outbreaks Dust Facility Design And Construction Female Histoplasmosis Humans Male Middle Aged Occupational Exposure Occupations Protective Devices Refuse Disposal Risk Factors Soil
Source:
Environ Health Perspect. 113(5):585-589.
Document Type:
Journal Article
Place as Subject:
Illinois
Collection(s):
CDC Public Access
Main Document Checksum:
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urn:sha256:1bba8d808f5789904e5f69d35b85f2e494afe38ed262a3548c40698c72f179af
Download URL:
https://stacks.cdc.gov/view/cdc/3861/cdc_3861_DS1.pdf
File Type:

Supporting Files

• 	ehp0113-000585.nxml	txt
  	ehp0113-000585f1.gif	gif
  	ehp0113-000585f1.jpg	jpeg
  	ehp0113-000585f2.gif	gif
  	ehp0113-000585f2.jpg	jpeg
  	license.txt	txt

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