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Calculating total daily dose of opioids for safer dosage
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    Why is it important to calculate the total daily dosage of opioids? -- How much is 50 or 90 MME/day for commonly prescribed opioids? -- How should the total daily dose of opioids be calculated? -- How should providers use the total daily opioid dose in clinical practice?

    Higher Dosage, Higher Risk.

    Higher dosages of opioids are associated with higher risk of overdose and death—even relativelylow dosages (20-50 morphine milligram equivalents (MME) per day) increase risk. Higher dosages haven’t been shown to reduce pain over the long term. One randomized trial found no differencein pain or function between a more liberal opioid dose escalation strategy (with average final dosage 52 MME) and maintenance of current dosage (average final dosage 40 MME).

    Learn more: ww.cdc.gov/drugoverdose/prescribing/guideline.html

    Fact sheet for: Dowell D, Haegerich TM, Chou R. CDC Guideline for Prescribing Opioids for Chronic Pain — United States, 2016. MMWR Recomm Rep 2016;65:1–49.

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