B cell sub-types following acute malaria and associations with clinical immunity

Details

• Alternative Title:
  Malar J
• Personal Author:
  Sullivan, Richard T. ; Ssewanyana, Isaac ; Wamala, Samuel ; Nankya, Felistas ; Jagannathan, Prasanna ; Tappero, Jordan W. ; Mayanja-Kizza, Harriet ; Muhindo, Mary K. ; Arinaitwe, Emmanuel ; Kamya, Moses ; Dorsey, Grant ; Feeney, Margaret E. ; Riley, Eleanor M. ; Drakeley, Chris J. ; Greenhouse, Bryan ; Sullivan, Richard
• Description:
  Background
  
  Repeated exposure to Plasmodium falciparum is associated with perturbations in B cell sub-set homeostasis, including expansion atypical memory B cells. However, B cell perturbations immediately following acute malaria infection have been poorly characterized, especially with regard to their relationship with immunity to malaria.
  
  Methods
  
  To better understand the kinetics of B cell sub-sets following malaria, the proportions of six B cell sub-sets were assessed at five time points following acute malaria in four to 5 years old children living in a high transmission region of Uganda. B cell sub-set kinetics were compared with measures of clinical immunity to malaria—lower parasite density at the time of malaria diagnosis and recent asymptomatic parasitaemia.
  
  Results
  
  Atypical memory B cell and transitional B cell proportions increased following malaria. In contrast, plasmablast proportions were highest at the time of malaria diagnosis and rapidly declined following treatment. Increased proportions of atypical memory B cells were associated with greater immunity to malaria, whereas increased proportions of transitional B cells were associated with evidence of less immunity to malaria.
  
  Conclusions
  
  These findings highlight the dynamic changes in multiple B cell sub-sets following acute, uncomplicated malaria, and how these sub-sets are associated with developing immunity to malaria.
  
  
• Subjects:
  Atypical Memory B Cells Immunity Malaria Plasmablasts Plasma Cells Plasmodium Falciparum Research Transitional B Cells
• Source:
  Malar J. 15.
• Pubmed ID:
  26939776
• Pubmed Central ID:
  PMC4778296
• Document Type:
  Journal Article
• Funding:
  K23 AI100949/AI/NIAID NIH HHS/United States
• Volume:
  15
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:a1ad386945f8654b565a18ba61a7b0a7836a7ef6800f373b34aa1c4ac2233137
• Download URL:
  https://stacks.cdc.gov/view/cdc/38454/cdc_38454_DS1.pdf
• File Type:
  [PDF - 1.44 MB ]