Details:

Alternative Title:
Sex Transm Dis
Publisher's site:
http://dx.doi.org/10.1097/OLQ.0000000000000431
Personal Author:
Nowak, Rebecca G. ; Gravitt, Patti E. ; He, Xin ; Ketende, Sosthenes ; Anom, Wuese ; ... More +
Nowak, Rebecca G. ; Gravitt, Patti E. ; He, Xin ; Ketende, Sosthenes ; Anom, Wuese ; Omuh, Helen ; Blattner, William A. ; Charurat, Manhattan E. Less -
Description:
Background

Prevalence estimates of anal high-risk human papillomavirus (HR-HPV) are needed in sub-Saharan Africa where HIV is endemic. This study evaluated anal HR-HPV in Nigeria among HIV-positive and HIV-negative men who have sex with men (MSM) for future immunization recommendations.

Methods

We conducted a cross-sectional study to compare the prevalence of anal HR-HPV infections between 64 HIV-negative and 90 HIV-positive MSM. Multivariate Poisson regression analyses were used to examine demographic and behavioral risk factors associated with any HR-HPV infections.

Results

The median age of the 154 participants was 25 years (interquartile range [IQR]: 22-28, range: 16-38) and the median age at initiation of anal sex with another man was 16 years (IQR: 13-18, range: 7-29). The prevalence of anal HR-HPV was higher among HIV-positive than HIV-negative MSM (91.1% vs. 40.6%, p<0.001). In the multivariate analysis, HIV infection (adjusted prevalence ratio [aPR]: 2.02, 95% CI: 1.49-2.72), ten years or more since anal sexual debut (aPR: 1.26, 95% CI: 1.07-1.49), and concurrent relationships with men (aPR: 1.32, 95% CI: 1.04-1.67) were associated with increased anal HR-HPV prevalence.

Conclusions

Anal HR-HPV infection is high for young Nigerian MSM and rates are amplified in those co-infected with HIV. Providing universal coverage as well as catchup immunization for young MSM may be an effective anal cancer prevention strategy in Nigeria.


Subject:
[+]
Adolescent
Adult
Anal Canal
Anus Diseases
Anus Neoplasms
Coinfection
Cross-Sectional Studies
HIV Infections
HIV Seropositivity
Homosexuality, Male
Humans
Male
Papillomavirus Infections
Prevalence
Risk Factors
Sexual Behavior
Sexually Transmitted Diseases
Young Adult

Source:
Sex Transm Dis. 43(4):243-248.
Pubmed ID:
26967301
Pubmed Central ID:
PMC4789762
Document Type:
Journal Article
Funding:
U2G IPS000651/PHS HHS/United States ; R01 MH099001/MH/NIMH NIH HHS/United States ; U2G PS000651/PS/NCHHSTP CDC HHS/United States ; D43TW01041/TW/FIC NIH HHS/United States ; R01MH099001-01/MH/NIMH NIH HHS/United States ; ... More +
U2G IPS000651/PHS HHS/United States ; R01 MH099001/MH/NIMH NIH HHS/United States ; U2G PS000651/PS/NCHHSTP CDC HHS/United States ; D43TW01041/TW/FIC NIH HHS/United States ; R01MH099001-01/MH/NIMH NIH HHS/United States ; R01 AI120913/AI/NIAID NIH HHS/United States ; D43 TW001041/TW/FIC NIH HHS/United States Less -
Place as Subject:
Nigeria
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:3639cb727cbe9c72152be0ab1a683247dd8d00c3dc34e6b966d5460e71e68baf
File Type:

Supporting Files

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