Prevalence of anal high-risk human papillomavirus infections among HIV-positive and HIV-negative men who have sex with men (MSM) in Nigeria

Details

• Alternative Title:
  Sex Transm Dis
• Personal Author:
  Nowak, Rebecca G. ; Gravitt, Patti E. ; He, Xin ; Ketende, Sosthenes ; Anom, Wuese ; Omuh, Helen ; Blattner, William A. ; Charurat, Manhattan E.
• Description:
  Background
  
  Prevalence estimates of anal high-risk human papillomavirus (HR-HPV) are needed in sub-Saharan Africa where HIV is endemic. This study evaluated anal HR-HPV in Nigeria among HIV-positive and HIV-negative men who have sex with men (MSM) for future immunization recommendations.
  
  Methods
  
  We conducted a cross-sectional study to compare the prevalence of anal HR-HPV infections between 64 HIV-negative and 90 HIV-positive MSM. Multivariate Poisson regression analyses were used to examine demographic and behavioral risk factors associated with any HR-HPV infections.
  
  Results
  
  The median age of the 154 participants was 25 years (interquartile range [IQR]: 22-28, range: 16-38) and the median age at initiation of anal sex with another man was 16 years (IQR: 13-18, range: 7-29). The prevalence of anal HR-HPV was higher among HIV-positive than HIV-negative MSM (91.1% vs. 40.6%, p<0.001). In the multivariate analysis, HIV infection (adjusted prevalence ratio [aPR]: 2.02, 95% CI: 1.49-2.72), ten years or more since anal sexual debut (aPR: 1.26, 95% CI: 1.07-1.49), and concurrent relationships with men (aPR: 1.32, 95% CI: 1.04-1.67) were associated with increased anal HR-HPV prevalence.
  
  Conclusions
  
  Anal HR-HPV infection is high for young Nigerian MSM and rates are amplified in those co-infected with HIV. Providing universal coverage as well as catchup immunization for young MSM may be an effective anal cancer prevention strategy in Nigeria.
  
  
• Subjects:
  Adolescent Adult Anal Canal Anus Diseases Anus Neoplasms Coinfection Cross-Sectional Studies HIV Infections HIV Seropositivity Homosexuality, Male Humans Male Nigeria Papillomavirus Infections Prevalence Risk Factors Sexual Behavior Sexually Transmitted Diseases Young Adult

  More +
• Keywords:
  Africa Anal Human Papillomavirus HIV Men Who Have Sex With Men
• Source:
  Sex Transm Dis. 43(4):243-248
• Pubmed ID:
  26967301
• Pubmed Central ID:
  PMC4789762
• Document Type:
  Journal Article
• Funding:
  U2G IPS000651/PHS HHSUnited States/ ; R01 MH099001/MH/NIMH NIH HHSUnited States/ ; U2G PS000651/PS/NCHHSTP CDC HHSUnited States/ ; D43TW01041/TW/FIC NIH HHSUnited States/ ; R01MH099001-01/MH/NIMH NIH HHSUnited States/ ; R01 AI120913/AI/NIAID NIH HHSUnited States/ ; D43 TW001041/TW/FIC NIH HHSUnited States/
• Volume:
  43
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:3639cb727cbe9c72152be0ab1a683247dd8d00c3dc34e6b966d5460e71e68baf
• Download URL:
  https://stacks.cdc.gov/view/cdc/38434/cdc_38434_DS1.pdf
• File Type:
  [PDF - 283.49 KB ]