Prevalence of anal high-risk human papillomavirus infections among HIV-positive and HIV-negative men who have sex with men (MSM) in Nigeria
Published Date:Apr 2016
Source:Sex Transm Dis. 43(4):243-248.
Anal Human Papillomavirus
Men Who Have Sex With Men
Sexually Transmitted Diseases
Pubmed Central ID:PMC4789762
Funding:U2G IPS000651/PHS HHS/United States
R01 MH099001/MH/NIMH NIH HHS/United States
U2G PS000651/PS/NCHHSTP CDC HHS/United States
D43TW01041/TW/FIC NIH HHS/United States
R01MH099001-01/MH/NIMH NIH HHS/United States
R01 AI120913/AI/NIAID NIH HHS/United States
D43 TW001041/TW/FIC NIH HHS/United States
Prevalence estimates of anal high-risk human papillomavirus (HR-HPV) are needed in sub-Saharan Africa where HIV is endemic. This study evaluated anal HR-HPV in Nigeria among HIV-positive and HIV-negative men who have sex with men (MSM) for future immunization recommendations.
We conducted a cross-sectional study to compare the prevalence of anal HR-HPV infections between 64 HIV-negative and 90 HIV-positive MSM. Multivariate Poisson regression analyses were used to examine demographic and behavioral risk factors associated with any HR-HPV infections.
The median age of the 154 participants was 25 years (interquartile range [IQR]: 22-28, range: 16-38) and the median age at initiation of anal sex with another man was 16 years (IQR: 13-18, range: 7-29). The prevalence of anal HR-HPV was higher among HIV-positive than HIV-negative MSM (91.1% vs. 40.6%, p<0.001). In the multivariate analysis, HIV infection (adjusted prevalence ratio [aPR]: 2.02, 95% CI: 1.49-2.72), ten years or more since anal sexual debut (aPR: 1.26, 95% CI: 1.07-1.49), and concurrent relationships with men (aPR: 1.32, 95% CI: 1.04-1.67) were associated with increased anal HR-HPV prevalence.
Anal HR-HPV infection is high for young Nigerian MSM and rates are amplified in those co-infected with HIV. Providing universal coverage as well as catchup immunization for young MSM may be an effective anal cancer prevention strategy in Nigeria.
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