Details:

Alternative Title:
Parkinsonism Relat Disord
Publisher's site:
http://dx.doi.org/10.1016/j.parkreldis.2015.12.005
Personal Author:
Taylor, Kathryn M. ; Saint-Hilaire, Marie-Helene ; Sudarsky, Lewis ; Simon, David K. ; Hersh, Bonnie ; ... More +
Taylor, Kathryn M. ; Saint-Hilaire, Marie-Helene ; Sudarsky, Lewis ; Simon, David K. ; Hersh, Bonnie ; Sparrow, David ; Hu, Howard ; Weisskopf, Marc G. Less -
Description:
Introduction

The literature on the effect of head injuries on the risk of PD is inconclusive. Some researchers have hypothesized that studies that have seen an effect are simply capturing injury related to pre-clinical PD. However in animal models brain inflammation, which can be initiated by head trauma, has been shown to produce PD-like effects. Furthermore, animal studies have found that early life inflammation in particular is of relevance for PD pathology.

Methods

We conducted an unmatched case-control study of 379 neurologist confirmed PD patients and 230 controls from the greater Boston, Massachusetts area with questionnaire data on history of head injury and other covariates. We used multivariable logistic regression to estimate adjusted odds ratios (OR) and their corresponding 95% confidence intervals (CI) for PD.

Results

When we excluded injuries that occurred less than 10 years prior to the diagnosis of PD (in order to avoid reverse causation), we found an increased risk of PD associated with a head injury that resulted in a loss of consciousness, but it did not reach statistical significance (OR= 1.57; 95% CI= 0.89-2.80). We found a significant (p=0.04) effect of age at first head injury. For every 5 year earlier age at first head injury with loss of consciousness the OR for PD was 1.37 (95% CI: 1.01-1.86).

Conclusion

Our results suggest that head injury in early life increases the risk of PD.


Subject:
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Adolescent Aged Article Case-Control Studies Child Craniocerebral Trauma Female Head Injury Humans Male Middle Aged Odds Ratio Parkinson's Disease Parkinson Disease Risk Factors Surveys And Questionnaires Traumatic Brain Injury
Source:
Parkinsonism Relat Disord. 23:57-61.
Pubmed ID:
26725141
Pubmed Central ID:
PMC4787263
Document Type:
Journal Article
Funding:
R01 ES010798/ES/NIEHS NIH HHS/United States ; T42 OH008416/OH/NIOSH CDC HHS/United States ; P30 ES000002/ES/NIEHS NIH HHS/United States ; P01-ES000002/ES/NIEHS NIH HHS/United States ; R01-ES010798/ES/NIEHS NIH HHS/United States ; ... More +
R01 ES010798/ES/NIEHS NIH HHS/United States ; T42 OH008416/OH/NIOSH CDC HHS/United States ; P30 ES000002/ES/NIEHS NIH HHS/United States ; P01-ES000002/ES/NIEHS NIH HHS/United States ; R01-ES010798/ES/NIEHS NIH HHS/United States ; R25 GM055353/GM/NIGMS NIH HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:c7a602fe7437db451554b1c72b34f524c737bf51c65390fcdb0bb20e991bd72f
Download URL:
https://stacks.cdc.gov/view/cdc/38421/cdc_38421_DS1.pdf
File Type:

Supporting Files

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