Modification by ALAD of the Association between Blood Lead and Blood Pressure in the U.S. Population: Results from the Third National Health and Nutrition Examination Survey

Details

• Alternative Title:
  Environ Health Perspect
• Personal Author:
  Scinicariello, Franco ; Yesupriya, Ajay ; Chang, Man-huei ; Fowler, Bruce A.
• Description:
  Background
  
  Environmental lead exposure has been found to be associated with an increased risk of hypertension. Individuals vary greatly in susceptibility to lead toxicity, and genetic susceptibility has often been cited as the probable cause for such variation.
  
  Objective
  
  The main objective is to determine the role of the aminolevulinic acid dehydratase (ALAD) gene, which encodes the main carrier protein of lead in blood, in the association between lead exposure and blood pressure (BP) and hypertension in the U.S. population.
  
  Methods
  
  We analyzed data from individuals ≥ 17 years of age who participated in the Third National Health and Nutrition Examination Survey for whom DNA was available (n = 6,016). Multivariable logistic and linear regressions stratified by race/ethnicity were used to examine whether hypertension and BP were associated with ALAD and blood lead levels (BLL).
  
  Results
  
  BLL was associated with systolic BP in non-Hispanic whites and with hypertension and systolic and diastolic BP in non-Hispanic blacks. BLL was not associated with BP outcomes in Mexican Americans. Non-Hispanic white ALAD2 carriers in the highest BLL quartile (3.8–52.9 μg/dL) had a significantly higher adjusted prevalence odds ratio for hypertension compared with ALAD1 homozygous individuals. We also found a significant interaction between lead concentration and the ALAD2 allele in non-Hispanic whites and non-Hispanic blacks in relation to systolic BP.
  
  Conclusions
  
  BLL may be an important risk factor for hypertension and increased systolic and diastolic BP. These associations may be modified by ALAD genotype.
  
  
• Subjects:
  Adolescent Adult ALAD Polymorphism Blood Pressure Female Genetic Predisposition To Disease Humans Hypertension Lead Male Middle Aged NHANES Polymorphism, Genetic Porphobilinogen Synthase Research Young Adult

  More +
• Source:
  Environ Health Perspect. 118(2):259-264.
• Document Type:
  Journal Article
• Volume:
  118
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:26f92f645513fe4cb61536c367fe88f2ce54443a700d1fd4a183a3fa354653a1
• Download URL:
  https://stacks.cdc.gov/view/cdc/3809/cdc_3809_DS1.pdf
• File Type:
  [PDF - 657.35 KB ]