Details:

Alternative Title:
Environ Health Perspect
Personal Author:
Shim, Youn K. ; Mlynarek, Steven P. ; van Wijngaarden, Edwin
Shim, Youn K. ; Mlynarek, Steven P. ; van Wijngaarden, Edwin Less -
Description:
Background

The etiology of childhood brain cancer remains largely unknown. However, previous studies have yielded suggestive associations with parental pesticide use.

Objectives

We aimed to evaluate parental exposure to pesticides at home and on the job in relation to the occurrence of brain cancer in children.

Methods

We included 526 one-to-one–matched case–control pairs. Brain cancer cases were diagnosed at < 10 years of age, and were identified from statewide cancer registries of four U.S. Atlantic Coast states. We selected controls by random digit dialing. We conducted computer-assisted telephone interviews with mothers. Using information on residential pesticide use and jobs held by fathers during the 2-year period before the child’s birth, we assessed potential exposure to insecticides, herbicides, and fungicides. For each job, two raters independently classified the probability and intensity of exposure; 421 pairs were available for final analysis. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) using conditional logistic regression, after adjustment for maternal education.

Results

A significant risk of astrocytoma was associated with exposures to herbicides from residential use (OR = 1.9; 95% CI, 1.2–3.0). Combining parental exposures to herbicides from both residential and occupational sources, the elevated risk remained significant (OR = 1.8; 95% CI, 1.1–3.1). We observed little association with primitive neuroectodermal tumors (PNET) for any of the pesticide classes or exposure sources considered.

Conclusions

Our observation is consistent with a previous literature reporting suggestive associations between parental exposure to pesticides and risk of astrocytoma in offspring but not PNET. However, these findings should be viewed in light of limitations in exposure assessment and effective sample size.


Subjects:
[+]
Astrocytoma Brain Brain Cancer Brain Neoplasms Child Child, Preschool Children Environmental Pollutants Female Humans Infant Male Maternal Exposure Parental Exposure Paternal Exposure Pesticides PNET Research Risk Factors Socioeconomic Factors
Source:
Environ Health Perspect. 117(6):1002-1006.
Document Type:
Journal Article
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:a0dd446e1d63f59db5a064fb6e5c1e78166bc4e949463399fe98177e96d60c8d
Download URL:
https://stacks.cdc.gov/view/cdc/3797/cdc_3797_DS1.pdf
File Type:

Supporting Files

• 	ehp-117-1002.nxml	txt
  	license.txt	txt

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