Attitudes of Clinicians Following Large-Scale Pharmacogenomics Implementation

Details

• Alternative Title:
  Pharmacogenomics J
• Personal Author:
  Peterson, Josh F. ; Field, Julie R. ; Shi, Yaping ; Schildcrout, Jonathan S. ; Denny, Joshua C. ; McGregor, Tracy L. ; Van Driest, Sara L. ; Pulley, Jill M. ; Lubin, Ira M. ; Laposata, Michael ; Roden, Dan M. ; Clayton, Ellen W.
• Description:
  Clinician attitudes toward multiplexed genomic testing may be vital to the success of translational programs. We surveyed clinicians at an academic medical center about their views on a large pharmacogenomics implementation, the PREDICT (Pharmacogenomic Resource for Enhanced Decisions in Care and Treatment) program. Participants were asked about test ordering, major factors influencing use of results, expectations of efficacy and responsibility for applying results to patient care. Virtually all respondents (99%) agreed that pharmacogenomics variants influence patients' response to drug therapy. The majority (92%) favored immediate, active notification when a clinically significant drug-genome interaction was present. However, clinicians were divided on which providers were responsible for acting on a result when a prescription change was indicated and whether patients should be directly notified of a significant result. We concluded genotype results were valued for tailoring prescriptions, but clinicians do not agree on how to appropriately assign clinical responsibility for actionable results from a multiplexed panel.The Pharmacogenomics Journal advance online publication, 11 August 2015; doi:10.1038/tpj.2015.57.
• Keywords:
  Adult Aged Attitude Of Health Personnel Drug-Related Side Effects And Adverse Reactions Female Genotype Health Knowledge, Attitudes, Practice Humans Male Middle Aged Perception Pharmacogenetics Pharmacogenomic Testing Pharmacogenomic Variants Phenotype Physicians Precision Medicine Predictive Value Of Tests Risk Assessment Risk Factors Surveys And Questionnaires Young Adult

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• Source:
  Pharmacogenomics J. 16(4):393-398
• Pubmed ID:
  26261062
• Pubmed Central ID:
  PMC4751074
• Document Type:
  Journal Article
• Funding:
  U01 HL105198/HL/NHLBI NIH HHSUnited States/ ; K23 HD000001/HD/NICHD NIH HHSUnited States/ ; U01 HL122904/HL/NHLBI NIH HHSUnited States/ ; U19 HL065962/HL/NHLBI NIH HHSUnited States/ ; U47 CI000824/CI/NCPDCID CDC HHSUnited States/ ; U01 HG008672/HG/NHGRI NIH HHSUnited States/ ; KL2 TR000446/TR/NCATS NIH HHSUnited States/ ; U01 HG006378/HG/NHGRI NIH HHSUnited States/ ; U01 HG007253/HG/NHGRI NIH HHSUnited States/ ; UL1 TR000445/TR/NCATS NIH HHSUnited States/
• Volume:
  16
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:31a62cd6605f2c88dd21547c08915fd390dcceb30dc4e71d1e49fb88de5060c3
• Download URL:
  https://stacks.cdc.gov/view/cdc/37968/cdc_37968_DS1.pdf
• File Type:
  [PDF - 801.99 KB ]