Welcome to CDC stacks | Maternal Serum 25-Hydroxyvitamin D Concentrations during Pregnancy and Infant Birthweight for Gestational Age: A Three-Cohort Study - 37961 | CDC Public Access
Stacks Logo
Advanced Search
Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.
Clear All Simple Search
Advanced Search
Maternal Serum 25-Hydroxyvitamin D Concentrations during Pregnancy and Infant Birthweight for Gestational Age: A Three-Cohort Study
Filetype[PDF-348.47 KB]

  • Pubmed ID:
  • Pubmed Central ID:
  • Description:

    In response to inconsistent findings, we investigated associations between maternal serum 25-hydroxyvitamin D (25(OH)D) concentrations and infant birthweight for gestational age (BW/GA), including potential effect modification by maternal race/ethnicity and infant sex.


    Data from 2,558 pregnant women were combined in a nested case-control study (preterm and term) sampled from three cohorts: the Omega study, the Pregnancy, Infection and Nutrition study, and the Pregnancy Outcomes and Community Health study. Maternal 25(OH)D concentrations were sampled at 4 to 29 weeks’ gestation (80% 14–26 weeks). BW/GA was modeled as sex-and gestational age-specific birthweight z-scores. General linear regression models (adjusting for age, education, parity, pre-pregnancy body mass index, season at blood draw, and smoking) assessed 25(OH)D concentrations in relation to BW/GA.


    Among non-Hispanic Black women, the positive association between 25(OH)D concentrations and BW/GA was of similar magnitude in pregnancies with female or male infants (beta (β)=0.015, standard error (SE)=0.007, P=0.025; β=0.018, SE=0.006, P=0.003, respectively). Among non-Hispanic White women, 25(OH)D-BW/GA association was observed only with male infants and the effect size was lower (β=0.008, SE=0.003, P=0.02).


    Maternal serum concentrations of 25(OH)D in early and mid-pregnancy were positively associated with BW/GA among non-Hispanic Black male and female infants and non-Hispanic White male infants. Effect modification by race/ethnicity may be due, in part, to overall lower concentrations of 25(OH)D in non-Hispanic Blacks. Reasons for effect modification by infant sex remain unclear.

  • Document Type:
  • Collection(s):
  • Funding:
    R01 HD34543/HD/NICHD NIH HHS/United States
    M01 RR000046/RR/NCRR NIH HHS/United States
    R01 HD039373/HD/NICHD NIH HHS/United States
    HD28684A/HD/NICHD NIH HHS/United States
    R01 HD034543/HD/NICHD NIH HHS/United States
    RR0046/RR/NCRR NIH HHS/United States
    HD39373/HD/NICHD NIH HHS/United States
    R01 HD32562/HD/NICHD NIH HHS/United States
    R01 HD28684/HD/NICHD NIH HHS/United States
    CC999999/Intramural CDC HHS/United States
    U01 DP000143/DP/NCCDPHP CDC HHS/United States
    R01 HD032562/HD/NICHD NIH HHS/United States
    HD37584/HD/NICHD NIH HHS/United States
    R01 HD037584/HD/NICHD NIH HHS/United States
    R24 HD050924/HD/NICHD NIH HHS/United States
    P2C HD050924/HD/NICHD NIH HHS/United States
    200-2008-27956-12/PHS HHS/United States
No Related Documents.
You May Also Like: