Details:

Alternative Title:
Infect Control Hosp Epidemiol
Publisher's site:
http://dx.doi.org/10.1086/673986
Personal Author:
Belay, Ermias D. ; Blase, Jennifer ; Sehulster, Lynne M. ; Maddox, Ryan A. ; Schonberger, Lawrence B.
Belay, Ermias D. ; Blase, Jennifer ; Sehulster, Lynne M. ; Maddox, Ryan A. ; Schonberger, Lawrence B. Less -
Description:
OBJECTIVE

To summarize the approaches used to manage exposure of patients to inadequately sterilized neurosurgical instruments contaminated as a result of Creutzfeldt-Jakob disease (CJD).

METHODS

Information on past CJD exposure incidents reported to the Centers for Disease Control and Prevention (CDC) was aggregated and summarized. In addition, inactivation studies were reviewed, and data from selected publications were provided for reference.

RESULTS

Nineteen incidents of patient exposure to potentially CJD-contaminated instruments were reported to the CDC, including 17 that involved intracranial procedures and 2 that involved ophthalmologic procedures. In more than 50% of incidents, the neurosurgical procedures were performed for diagnostic work up of the index patients. At least 12 of the hospitals had multiple neurosurgical sets, and the CJD-contaminated instruments could not be identified in 11 of 19 hospitals. In 12 of 15 hospitals with neurosurgical incidents, a decision was made to notify patients of their potential exposure.

CONCLUSIONS

Neurosurgical instruments used for treatment of patients with suspected or diagnosed CJD or patients whose diagnosis is unclear should be promptiy identified and sterilized using recommended CJD decontamination protocols. Inability to trace instruments complicates appropriate management of exposure incidents. The feasibility of instituting instrument tracking procedures should be considered.


Subject:
[+]
Adult
Aged
Aged, 80 And Over
Article
Creutzfeldt-Jakob Syndrome
Decontamination
Female
Humans
Male
Middle Aged
Neurosurgery
Ophthalmologic Surgical Procedures
Prions
Sterilization
Surgical Instruments

Source:
Infect Control Hosp Epidemiol. 34(12):1272-1280.
Pubmed ID:
24225612
Pubmed Central ID:
PMC4748700
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:396cf62f64b76dcca91ff4dc60d5c6d34f3677cd1a56989bfa0135f96436dcfc
File Type:

Supporting Files

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