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Hospitalizations and Outpatient Visits for Rhinovirus - Associated Acute Respiratory Illness in Adults
  • Published Date:
    Aug 06 2015
  • Source:
    J Allergy Clin Immunol. 137(3):734-743.e1.

Public Access Version Available on: March 01, 2017 information icon
Please check back on the date listed above.
  • Pubmed ID:
  • Pubmed Central ID:
  • Funding:
    5UL1 RR024975-03/RR/NCRR NIH HHS/United States
    AI101629/AI/NIAID NIH HHS/United States
    G20 RR030956/RR/NCRR NIH HHS/United States
    P30 CA68485/CA/NCI NIH HHS/United States
    P30 EY08126/EY/NEI NIH HHS/United States
    R03 AI101629/AI/NIAID NIH HHS/United States
    U18 1P000184/PHS HHS/United States
    U18 IP000184/IP/NCIRD CDC HHS/United States
    UL1 RR024975/RR/NCRR NIH HHS/United States
    UL1 TR000445/TR/NCATS NIH HHS/United States
    UL1 TR000445/TR/NCATS NIH HHS/United States
  • Document Type:
  • Description:

    Rhinovirus is linked to asthma exacerbations and chronic obstructive pulmonary disease exacerbations in adults. The severity and rates of rhinovirus acute respiratory illnesses (ARI) in adults are uncertain.


    We determined rhinovirus-associated ARI rates in adults presenting for care in multiple settings and identified factors associated with rhinovirus detection.


    This prospective, population-based cohort enrolled Tennessee residents ≥18 years old in the emergency department (ED), outpatient clinics, or hospitalized for ARI December 2008-May 2010. Nasal/throat swabs were collected and tested for rhinovirus and other viruses by RT-PCR. Rates of ED visits and hospitalizations were calculated and rhinovirus-positive and -negative patients were compared.


    Among 2351 enrollees, rhinovirus was detected in 247 (11%). There were 7 rhinovirus-associated ED visits and 3 hospitalizations per 1000 adults annually. Patients with rhinovirus, compared to virus-negative ARI, were more likely to present with wheezing (odds ratio [OR] 1.7, 95% confidence interval [CI] 1.23-2.35, p<0.001), to be a current smoker (OR 2.31, CI 1.68-3.19) or live with a smoker (OR 1.72, CI 1.10-2.67), have a history of chronic respiratory disease (OR 1.61, CI 1.17-2.22), and were less likely to be hospitalized versus seen in the outpatient setting (OR 0.58, CI 0.41-0.83).


    Rhinovirus is associated with a substantial number of ED visits and hospitalizations for ARI in adults. There may be modifiable factors that can reduce the likelihood of presenting with rhinovirus-associated ARI.

  • Supporting Files:
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