Hospitalizations and Outpatient Visits for Rhinovirus - Associated Acute Respiratory Illness in Adults

Details

• Alternative Title:
  J Allergy Clin Immunol
• Personal Author:
  Miller, E. Kathryn ; Linder, Jodell ; Kraft, David ; Johnson, Monika ; Lu, Pengcheng ; Saville, Benjamin R. ; Williams, John V. ; Griffin, Marie R. ; Talbot, H. Keipp
• Description:
  Background
  
  Rhinovirus is linked to asthma exacerbations and chronic obstructive pulmonary disease exacerbations in adults. The severity and rates of rhinovirus acute respiratory illnesses (ARI) in adults are uncertain.
  
  Objectives
  
  We determined rhinovirus-associated ARI rates in adults presenting for care in multiple settings and identified factors associated with rhinovirus detection.
  
  Methods
  
  This prospective, population-based cohort enrolled Tennessee residents ≥18 years old in the emergency department (ED), outpatient clinics, or hospitalized for ARI December 2008-May 2010. Nasal/throat swabs were collected and tested for rhinovirus and other viruses by RT-PCR. Rates of ED visits and hospitalizations were calculated and rhinovirus-positive and -negative patients were compared.
  
  Results
  
  Among 2351 enrollees, rhinovirus was detected in 247 (11%). There were 7 rhinovirus-associated ED visits and 3 hospitalizations per 1000 adults annually. Patients with rhinovirus, compared to virus-negative ARI, were more likely to present with wheezing (odds ratio [OR] 1.7, 95% confidence interval [CI] 1.23-2.35, p<0.001), to be a current smoker (OR 2.31, CI 1.68-3.19) or live with a smoker (OR 1.72, CI 1.10-2.67), have a history of chronic respiratory disease (OR 1.61, CI 1.17-2.22), and were less likely to be hospitalized versus seen in the outpatient setting (OR 0.58, CI 0.41-0.83).
  
  Conclusion
  
  Rhinovirus is associated with a substantial number of ED visits and hospitalizations for ARI in adults. There may be modifiable factors that can reduce the likelihood of presenting with rhinovirus-associated ARI.
  
  
• Subjects:
  Acute Disease Adolescent Adult Aged Aged, 80 And Over Ambulatory Care Article Emergency Service, Hospital Female Hospitalization Humans Male Middle Aged Odds Ratio Picornaviridae Infections Prevalence Public Health Surveillance Respiratory Sounds Respiratory Tract Infections Risk Factors Seasons Young Adult

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• Source:
  J Allergy Clin Immunol. 137(3):734-743.e1
• Pubmed ID:
  26255695
• Pubmed Central ID:
  PMC4744574
• Document Type:
  Journal Article
• Funding:
  UL1 TR000445/TR/NCATS NIH HHS/United States ; 5UL1 RR024975-03/RR/NCRR NIH HHS/United States ; P30 CA68485/CA/NCI NIH HHS/United States ; R03 AI101629/AI/NIAID NIH HHS/United States ; AI101629/AI/NIAID NIH HHS/United States ; P30 EY008126/EY/NEI NIH HHS/United States ; P30 CA068485/CA/NCI NIH HHS/United States ; UL1 RR024975/RR/NCRR NIH HHS/United States ; U18 1P000184/PHS HHS/United States ; P30 EY08126/EY/NEI NIH HHS/United States ; U18 IP000184/IP/NCIRD CDC HHS/United States ; G20 RR030956/RR/NCRR NIH HHS/United States
• Place as Subject:
  Tennessee
• Volume:
  137
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:8f6ab86b9bb5f63af00ff502aac9ec7fc90a3f60276aa8a3ce19f1b6e43c2642
• Download URL:
  https://stacks.cdc.gov/view/cdc/37881/cdc_37881_DS1.pdf
• File Type:
  [PDF - 2.26 MB ]