Does Processing Speed Mediate the Effect of Pediatric Traumatic Brain Injury on Working Memory?

Gorman, Stephanie; Barnes, Marcia A.; Swank, Paul; Prasad, Mary; Cox, Charles S.; Ewing-Cobbs, Linda

doi:10.1037/neu0000214

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Does Processing Speed Mediate the Effect of Pediatric Traumatic Brain Injury on Working Memory?

3 2016
By Gorman, Stephanie ; Barnes, Marcia A. ; Swank, Paul ; ...
http://dx.doi.org/10.1037/neu0000214
Source: Neuropsychology. 30(3):263-273

[PDF-183.51 KB]

English

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Details:

Alternative Title:

Neuropsychology
Personal Author:

Gorman, Stephanie ; Barnes, Marcia A. ; Swank, Paul ; Prasad, Mary ; Cox, Charles S. ; ... More +

Gorman, Stephanie ; Barnes, Marcia A. ; Swank, Paul ; Prasad, Mary ; Cox, Charles S. ; Ewing-Cobbs, Linda Less -
Description:

Objective

Processing speed (PS) and working memory (WM), core abilities that support learning, are vulnerable to disruption following traumatic brain injury (TBI). Developmental increases in WM are related to age-related changes in PS. The purpose of this study was to investigate whether WM deficits in children with TBI are mediated by PS.

Method

The performance of children with complicated-mild, moderate, and severe TBI (n=77) was examined relative to an orthopedic injury (n=30) and a healthy comparison group (n=40) an average of 4 years after injury (range 8 months to 12 years). Coding was utilized as a measure of PS, while the WM measures included complex verbal and visual-spatial span tasks with parallel processing requirements. Mediation analysis examined whether TBI might have an indirect effect on WM through PS.

Results

Children in the TBI group performed more poorly than the combined comparison groups on Coding and visual-spatial WM. Verbal WM scores were lower in TBI and the healthy comparison relative to the orthopedic group. TBI severity group differences were found on Coding, but not WM measures. The relation between Coding and both the WM tasks was similar. Bootstrap regression analyses suggested that PS, as measured by Coding, might partially mediate the effect of group performance on WM.

Conclusions

TBI disrupts core PS and WM abilities that scaffold more complex abilities. Importantly, slowed PS was associated with WM deficits commonly identified following pediatric TBI. Implications of our findings regarding the relation between PS and WM may suggest interventions for children and adolescents following TBI.
Keywords:

[+]

Adolescent Auditory Perception Brain Injuries Child Child, Preschool Cohort Studies Educational Status Female Glasgow Coma Scale Humans Infant Intelligence Tests Longitudinal Studies Male Mediation Model Memory, Short-Term Memory Disorders Mothers Outcome Processing Speed Prospective Studies Psychomotor Performance Traumatic Brain Injury Working Memory
Source:

Neuropsychology. 30(3):263-273
Pubmed ID:

26214659
Pubmed Central ID:

PMC4729671
Document Type:

Journal Article
Funding:

R01 NS046308/NS/NINDS NIH HHSUnited States/ ; U01 CE002188/CE/NCIPC CDC HHSUnited States/ ; UL1 TR000371/TR/NCATS NIH HHSUnited States/ ; R01NS046308/NS/NINDS NIH HHSUnited States/

R01 NS046308/NS/NINDS NIH HHSUnited States/ ; U01 CE002188/CE/NCIPC CDC HHSUnited States/ ; UL1 TR000371/TR/NCATS NIH HHSUnited States/ ; R01NS046308/NS/NINDS NIH HHSUnited States/ Less -
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:5dac84992b76ea44b7ec89ce9216232d3eb304a34fe2b9bcb724da2f21745d4d
Download URL:

https://stacks.cdc.gov/view/cdc/37811/cdc_37811_DS1.pdf
File Type:

nihms-699548.nxml

xml

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