Health assessment of gasoline and fuel oxygenate vapors: Reproductive toxicity assessment

Details

• Alternative Title:
  Regul Toxicol Pharmacol
• Personal Author:
  Gray, Thomas M. ; Steup, David ; Roberts, Linda G. ; O'Callaghan, James P. ; Hoffman, Gary ; Schreiner, Ceinwen A. ; Clark, Charles R.
• Description:
  Vapor condensates of baseline gasoline (BGVC), or gasoline-blended with methyl tertiary butyl ether (G/MTBE), ethyl t-butyl ether (G/ETBE), t-amyl methyl ether (G/TAME), diisopropyl ether (G/DIPE), ethanol (G/EtOH), or t-butyl alcohol (G/TBA) were evaluated for reproductive toxicity in rats at target concentrations of 2000, 10,000, or 20,000mg/m(3), 6h/day, 7days/week. BGVC and G/MTBE were assessed over two generations, the others for one generation. BGVC and G/MTBE F1 offspring were evaluated for neuropathology and changes in regional brain glial fibrillary acidic protein content. No neurotoxicity was observed. Male kidney weight was increased consistent with light hydrocarbon nephropathy. In adult rats, decreased body weight gain and increased liver weight were seen. Spleen weight decreased in adults and pups exposed to G/TBA. No pathological changes to reproductive organs occurred in any study. Decreased food consumption was seen in G/TAME lactating females. Transient decreases in G/TAME offspring weights were observed during lactation. Except for a minor increase in time to mating in G/TBA which did not affect other reproductive parameters, there were no adverse reproductive findings. The NOAEL for reproductive and offspring parameters was 20,000mg/m(3) for all vapor condensates except for lower offspring NOAELs of 10,000mg/m(3) for G/TBA and 2000mg/m(3) for G/TAME.
• Subjects:
  Air Pollutants Animals Article Diisopropyl Ether (DIPE) Ethanol (EtOH) Ethyl Tert Butyl Ether (ETBE) Female Fuel Oxygenates Gasoline Gasoline Vapor Condensates Glial Fibrillary Acid Protein Inhalation Male Methyl Tert-butyl Ether (MTBE) Rats Rats, Sprague-Dawley Reproduction Reproductive Toxicity Risk Assessment T-Amyl Methyl Ether (TAME) T-Butyl Alcohol (TBA) Toxicity Tests

  More +
• Source:
  Regul Toxicol Pharmacol. 70(2 0):S48-S57.
• Pubmed ID:
  24813181
• Pubmed Central ID:
  PMC4722801
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States
• Volume:
  70
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:eda2158d69fc40c829ce2f8f5a10a5f1844a957ac43cab56e431a0b49a2b3f1d
• Download URL:
  https://stacks.cdc.gov/view/cdc/37670/cdc_37670_DS1.pdf
• File Type:
  [PDF - 520.43 KB ]