Sleep disruption and the sequelae associated with traumatic brain injury

Details

• Alternative Title:
  Neurosci Biobehav Rev
• Personal Author:
  Lucke-Wold, Brandon P. ; Smith, Kelly E. ; Nguyen, Linda ; Turner, Ryan C. ; Logsdon, Aric F. ; Jackson, Garrett J. ; Huber, Jason D. ; Rosen, Charles L. ; Miller, Diane B.
• Description:
  Sleep disruption, which includes a loss of sleep as well as poor quality fragmented sleep, frequently follows traumatic brain injury (TBI) impacting a large number of patients each year in the United States. Fragmented and/or disrupted sleep can worsen neuropsychiatric, behavioral, and physical symptoms of TBI. Additionally, sleep disruption impairs recovery and can lead to cognitive decline. The most common sleep disruption following TBI is insomnia, which is difficulty staying asleep. The consequences of disrupted sleep following injury range from deranged metabolomics and blood brain barrier compromise to altered neuroplasticity and degeneration. There are several theories for why sleep is necessary (e.g., glymphatic clearance and metabolic regulation) and these may help explain how sleep disruption contributes to degeneration within the brain. Experimental data indicate disrupted sleep allows hyperphosphorylated tau and amyloid β plaques to accumulate. As sleep disruption may act as a cellular stressor, target areas warranting further scientific investigation include the increase in endoplasmic reticulum and oxidative stress following acute periods of sleep deprivation. Potential treatment options for restoring the normal sleep cycle include melatonin derivatives and cognitive behavioral therapy.
• Keywords:
  Adenosine Triphosphate Amyloid Beta-Peptides Animals Blood-Brain Barrier Brain Injuries Cognition Disorders Disease Progression Humans Maintenance Insomnia Melatonin Neurodegeneration Neuropsychiatric Symptoms Sleep Disruption Sleep Wake Disorders Traumatic Brain Injury

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• Source:
  Neurosci Biobehav Rev. 55:68-77
• Pubmed ID:
  25956251
• Pubmed Central ID:
  PMC4721255
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHSUnited States/
• Volume:
  55
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:ca9363473557dbf468aea8d35077070113d1f4d0a5294eae240506b2aea40515
• Download URL:
  https://stacks.cdc.gov/view/cdc/37664/cdc_37664_DS1.pdf
• File Type:
  [PDF - 1.35 MB ]