Characterization of SPECTRUM Variable Nicotine Research Cigarettes

Details

• Alternative Title:
  Tob Regul Sci
• Personal Author:
  Richter, Patricia ; Steven, Pappas R. ; Bravo, Roberto ; Lisko, Joseph G. ; Damian, Maria ; Gonzalez-Jimenez, Nathalie ; Gray, Naudia ; Keong, Lisa M. ; Kimbrell, Jacob B. ; Kuklenyik, Peter ; Lawler, Tameka S. ; Lee, Grace E. ; Mendez, Magaly ; Perez, Jose ; Smith, Shakia ; Tran, Hang ; Tyx, Robert ; Watson, Clifford H.
• Description:
  Objective
  
  To provide researchers an extensive characterization of the SPECTRUM variable nicotine research cigarettes.
  
  Methods
  
  Data on cigarette physical properties, nicotine content, harmful and potentially harmful constituents in the tobacco filler was compiled.
  
  Results
  
  Data on physical properties, concentrations of menthol, nicotine and minor alkaloids, tobacco-specific nitrosamines, polycyclic aromatic hydrocarbons, ammonia, and toxic metals in the filler tobacco for all available varieties of Spectrum research cigarettes are provided. The similarity in the chemistry and physical properties of SPECTRUM cigarettes to commercial cigarettes renders them acceptable for use in behavioral studies. Baseline information on harmful and potentially harmful constituents in research tobacco products, particularly constituent levels such as minor alkaloids that fall outside typical ranges reported for commercial, provide researchers with the opportunity to monitor smoking behavior and to identify biomarkers that will inform efforts to understand the role of nicotine in creating and sustaining addiction.
  
  Conclusions
  
  Well characterized research cigarettes suitable for human consumption are an important tool in clinical studies for investigating the physiological impacts of cigarettes delivering various levels of nicotine, the impact of reduced nicotine cigarettes on nicotine addiction, and the relationship between nicotine dose and smoking behavior.
  
  
• Keywords:
  Alkaloids Cigarettes Metals Nicotine PAH Spectrum Tobacco
• Source:
  Tob Regul Sci. 2(2):94-105
• Pubmed ID:
  26779559
• Pubmed Central ID:
  PMC4711912
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHSUnited States/
• Volume:
  2
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:17b36c405b4b4247508b32ad56f57eb3673b47b897f83fa632798556c0acfcc2
• Download URL:
  https://stacks.cdc.gov/view/cdc/37538/cdc_37538_DS1.pdf
• File Type:
  [PDF - 423.19 KB ]