The effects of carbon nanotubes on lung and dermal cellular behaviors

Details

• Alternative Title:
  Nanomedicine (Lond)
• Personal Author:
  Luanpitpong, Sudjit ; Wang, Liying ; Rojanasakul, Yon
• Description:
  Carbon nanotubes (CNTs) hold great promise to create new and better products, but their adverse health effect is a major concern. Human exposure to CNTs is primarily through inhalation and dermal contact, especially during the manufacturing and handling processes. Numerous animal studies have demonstrated the potential pulmonary and dermal hazards associated with CNT exposure, while in vitro studies have assessed the effects of CNT exposure on various cellular behaviors and have been used to perform mechanistic studies. In this review, we provide an overview of the pathological effects of CNTs and examine the acute and chronic effects of CNT exposure on lung and dermal cellular behaviors, beyond the generally discussed cytotoxicity. We then examine the linkage of cellular behaviors and disease pathogenesis, and discuss the pertinent mechanisms.
• Subjects:
  Angiogenesis Animals Article Carbon Nanotubes Carcinogenicity Carcinogens Cellular Behavior Cytotoxicity Dermal Exposure Genotoxicity Humans Inflammation Lung Lung Fibrosis Mutagens Nanotubes, Carbon Neovascularization, Pathologic Pulmonary Exposure Skin

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• Source:
  Nanomedicine (Lond). 9(6):895-912.
• Pubmed ID:
  24981653
• Pubmed Central ID:
  PMC4710349
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States ; R01-ES022968/ES/NIEHS NIH HHS/United States ; R01-HL095579/HL/NHLBI NIH HHS/United States
• Volume:
  9
• Issue:
  6
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:f28d058c67cb9d2fdeb160bd11f3868eb2af90a227ff173120e2b5add8e06eb8
• Download URL:
  https://stacks.cdc.gov/view/cdc/37528/cdc_37528_DS1.pdf
• File Type:
  [PDF - 1.00 MB ]