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Rotavirus.
  • Published Date:
    1998 Oct-Dec
  • Source:
    Emerg Infect Dis. 4(4):561-570.
  • Language:
    English
Filetype[PDF-356.44 KB]


Details:
  • Alternative Title:
    Emerg Infect Dis
  • Personal Author:
  • Description:
    Rotavirus, the most common diarrheal pathogen in children worldwide, causes approximately one third of diarrhea-associated hospitalizations and 800,000 deaths per year. Because natural infection reduces the incidence and severity of subsequent episodes, rotavirus diarrhea might be controlled through vaccination. Serotypespecific immunity may play a role in protection from disease. Tetravalent rhesus-human reassortant rotavirus vaccine (RRV-TV) (which contains a rhesus rotavirus with serotype G3 specificity and reassortant rhesus-human rotaviruses with G1, G2, and G4 specificity) provides coverage against the four common serotypes of human rotavirus. In clinical trials in industrialized countries, RRV-TV conferred 49% to 68% protection against any rotavirus diarrhea and 61% to 100% protection against severe disease. This vaccine was licensed by the U.S. Food and Drug Administration on August 31, 1998, and should be cost-effective in reducing diarrheal diseases in industrialized countries. The vaccine's efficacy and cost-effectiveness in developing countries should be evaluated.

  • Subject:
  • Document Type:
    Journal Article
  • Collection(s):
    Emerging Infectious Diseases
  • Main Document Checksum:
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