Details:

Alternative Title:
J Expo Sci Environ Epidemiol
Personal Author:
Poghosyan, Armen ; Morel-Espinosa, Maria ; Valentín-Blasini, Liza ; Blount, Benjamin C. ; Ferreccio, Catterina ; ... More +
Poghosyan, Armen ; Morel-Espinosa, Maria ; Valentín-Blasini, Liza ; Blount, Benjamin C. ; Ferreccio, Catterina ; Steinmaus, Craig M. ; Sturchio, Neil C. Less -
Description:
Perchlorate (ClO4(-)) is a ubiquitous environmental contaminant with high human exposure potential. Natural perchlorate forms in the atmosphere from where it deposits onto the surface of Earth, whereas synthetic perchlorate is manufactured as an oxidant for industrial, aerospace, and military applications. Perchlorate exposure can potentially cause adverse health effects in humans by interfering with the production of thyroid hormones through competitively blocking iodide uptake. To control and reduce perchlorate exposure, the contributions of different sources of perchlorate exposure need to be quantified. Thus, we demonstrate a novel approach for determining the contribution of different perchlorate exposure sources by quantifying stable and radioactive chlorine isotopes of perchlorate extracted from composite urine samples from two distinct populations: one in Atlanta, USA and one in Taltal, Chile (Atacama region). Urinary perchlorate from the Atlanta region resembles indigenous natural perchlorate from the western USA (δ(37)Cl=+4.1±1.0‰; (36)Cl/Cl=1 811 (±136) × 10(-15)), and urinary perchlorate from the Taltal, Chile region is similar to natural perchlorate in nitrate salt deposits from the Atacama Desert of northern Chile (δ(37)Cl=-11.0±1.0‰; (36)Cl/Cl=254 (±40) × 10(-15)). Neither urinary perchlorate resembled the isotopic pattern found in synthetic perchlorate. These results indicate that natural perchlorate of regional provenance is the dominant exposure source for the two sample populations, and that chlorine isotope ratios provide a robust tool for elucidating perchlorate exposure pathways.
Subjects:
[+]
Article Chlorine Environmental Exposure Humans Occupational Exposure Perchlorates
Source:
J Expo Sci Environ Epidemiol. 26(3):324-328.
Pubmed ID:
25805252
Pubmed Central ID:
PMC4707997
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:f8b2c97e3226a1b34ca91d0ccd7e3bbc344b7c156b010f771ef77beac02db03c
Download URL:
https://stacks.cdc.gov/view/cdc/37452/cdc_37452_DS1.pdf
File Type:

Supporting Files

• 	nihms-721197-f0001.gif	gif
  	nihms-721197-f0001.jpg	jpeg
  	nihms-721197.nxml	bin

More +