Cancer Incidence among Minnesota Taconite Mining Industry Workers
Published Date:Aug 29 2015
Source:Ann Epidemiol. 25(11):811-815.e1.
Air Pollutants, Occupational
Public Health Surveillance
Pubmed Central ID:PMC4576455
Funding:R25 CA163184/CA/NCI NIH HHS/United States
2T42 OH008434/OH/NIOSH CDC HHS/United States
R25CA163184/CA/NCI NIH HHS/United States
To evaluate cancer incidence among Minnesota Taconite mining workers.
We evaluated cancer incidence between 1988 and 2010 in a cohort of 40,720 Minnesota taconite mining workers employed between 1937 and 1983. Standardized incidence ratios (SIRs) with 95% confidence intervals (CI) were estimated by comparing numbers of incident cancers with frequencies in the Minnesota Cancer Surveillance System. SIRs for lung cancer by histological subtypes were also estimated. We adjusted for out-of-state migration and conducted a probabilistic bias analysis for smoking related cancers.
A total of 5,700 cancers were identified including 51 mesotheliomas and 973 lung cancers. The SIR for lung cancer and mesothelioma were 1.3 (95% CI: 1.2-1.4) and 2.4 (95% CI: 1.8-3.2) respectively. Stomach, laryngeal, and bladder cancers were also elevated. However, adjusting for potential confounding by smoking attenuated the estimates for lung (SIR=1.1, 95% CI: 1.0-1.3), laryngeal (SIR=1.2, 95% CI: 0.8-1.6), oral (SIR=0.9, 95% CI: 0.7-1.2), and bladder cancers (SIR=1.0, 95% CI: 0.8-1.1).
Taconite workers may have an increased risk for certain cancers. Lifestyle and work-related factors may play a role in elevated morbidity. The extent to which mining-related exposures contribute to disease burden is being investigated.
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