Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid2201.150139
Personal Author:
Moore, Luke S.P.; Owens, Daniel S.; Jepson, Annette; Turton, Jane F.; Ashworth, Simon; ... More +
Moore, Luke S.P.; Owens, Daniel S.; Jepson, Annette; Turton, Jane F.; Ashworth, Simon; Donaldson, Hugo; Holmes, Alison H.; Less -
Description:
Elizabethkingia meningoseptica is an infrequent colonizer of the respiratory tract; its pathogenicity is uncertain. In the context of a 22-month outbreak of E. meningoseptica acquisition affecting 30 patients in a London, UK, critical care unit (3% attack rate) we derived a measure of attributable morbidity and determined whether E. meningoseptica is an emerging nosocomial pathogen. We found monomicrobial E. meningoseptica acquisition (n = 13) to have an attributable morbidity rate of 54% (systemic inflammatory response syndrome >2, rising C-reactive protein, new radiographic changes), suggesting that E. meningoseptica is a pathogen. Epidemiologic and molecular evidence showed acquisition was water-source-associated in critical care but identified numerous other E. meningoseptica strains, indicating more widespread distribution than previously considered. Analysis of changes in gram-negative speciation rates across a wider London hospital network suggests this outbreak, and possibly other recently reported outbreaks, might reflect improved diagnostics and that E. meningoseptica thus is a pseudo-emerging pathogen.
Subject:
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Adolescent
Adult
Aged
Aged, 80 And Over
Anti-Bacterial Agents
C-Reactive Protein
Critical Care
Cross Infection
Disease Outbreaks
Female
Flavobacteriaceae
Flavobacteriaceae Infections
Humans
Incidence
Intensive Care Units
Male
Microbial Sensitivity Tests / Methods
Middle Aged
Young Adult

Source:
Emerg Infect Dis. 22(1):9-17.;
Pubmed ID:
26690562
Pubmed Central ID:
PMC4696684
Document Type:
Journal Article;
Place as Subject:
London, England;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:d4219455c95a8c2a235623ed2c01dc9ee3a7b5f33536afe39236c55cefb7bd69
File Type:

Supporting Files

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