Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Moore, Luke S.P. ; Owens, Daniel S. ; Jepson, Annette ; Turton, Jane F. ; Ashworth, Simon ; ... More +
Moore, Luke S.P. ; Owens, Daniel S. ; Jepson, Annette ; Turton, Jane F. ; Ashworth, Simon ; Donaldson, Hugo ; Holmes, Alison H. Less -
Description:
Elizabethkingia meningoseptica is an infrequent colonizer of the respiratory tract; its pathogenicity is uncertain. In the context of a 22-month outbreak of E. meningoseptica acquisition affecting 30 patients in a London, UK, critical care unit (3% attack rate) we derived a measure of attributable morbidity and determined whether E. meningoseptica is an emerging nosocomial pathogen. We found monomicrobial E. meningoseptica acquisition (n = 13) to have an attributable morbidity rate of 54% (systemic inflammatory response syndrome >2, rising C-reactive protein, new radiographic changes), suggesting that E. meningoseptica is a pathogen. Epidemiologic and molecular evidence showed acquisition was water-source-associated in critical care but identified numerous other E. meningoseptica strains, indicating more widespread distribution than previously considered. Analysis of changes in gram-negative speciation rates across a wider London hospital network suggests this outbreak, and possibly other recently reported outbreaks, might reflect improved diagnostics and that E. meningoseptica thus is a pseudo-emerging pathogen.
Subjects:
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Adolescent Adult Aged Aged, 80 And Over Anti-Bacterial Agents C-Reactive Protein Critical Care Cross Infection Disease Outbreaks Female Flavobacteriaceae Flavobacteriaceae Infections Humans Incidence Intensive Care Units Male Microbial Sensitivity Tests / Methods Middle Aged Young Adult
Source:
Emerg Infect Dis. 22(1):9-17.
Pubmed ID:
26690562
Pubmed Central ID:
PMC4696684
Document Type:
Journal Article
Place as Subject:
London, England
Location:
Europe
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:d4219455c95a8c2a235623ed2c01dc9ee3a7b5f33536afe39236c55cefb7bd69
Download URL:
https://stacks.cdc.gov/view/cdc/37264/cdc_37264_DS1.pdf
File Type:

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