Details:

Alternative Title:
Fertil Steril
Personal Author:
Grigorescu, Violanda ; Zhang, Yujia ; Kissin, Dmitry M. ; Sauber-Schatz, Erin ; Sunderam, Mithi ; ... More +
Grigorescu, Violanda ; Zhang, Yujia ; Kissin, Dmitry M. ; Sauber-Schatz, Erin ; Sunderam, Mithi ; Kirby, Russell S. ; Diop, Hafsatou ; McKane, Patricia ; Jamieson, Denise J. Less -
Description:
Objective

To examine differences in maternal characteristics and pregnancy outcomes between women with ovulatory dysfunction (OD) and women with tubal obstruction (TO) who underwent assisted reproductive technology (ART).

Design

Retrospective cohort study.

Setting

Centers for Disease Control and Prevention.

Patient(s)

Exposed and nonexposed groups were selected from the 2000–2006 National ART Surveillance System linked with live-birth certificates from three states: Florida, Massachusetts, and Michigan.

Intervention(s)

None.

Main Outcome Measure(s)

Maternal characteristics and pregnancy outcomes, including newborn’s health status right after delivery (Apgar score, <7 vs. ≥7) as the study outcome of interest, were assessed among women with OD/polycystic ovary syndrome (PCOS) and TO who used ART.

Result(s)

A significantly higher prevalence of women with OD/PCOS were younger (<35 years of age; 65.7% vs. 48.9%), were white (85.4% vs. 74.4%), had higher education (29.4% vs. 15.6%), and experienced diabetes (8.8% vs. 5.3%) compared with those having TO. The odds of having a lower (<7) Apgar score at 5 minutes were almost twice as high among newborns of women with OD/PCOS compared with those with TO (crude odds ratio, 1.86; 95% confidence interval [CI], 1.31, 2.64; adjusted odds ratio, 1.90; 95% CI, 1.30, 2.77).

Conclusion(s)

Women with OD/PCOS who underwent ART have different characteristics and health issues (higher prevalence of diabetes) and infant outcomes (lower Apgar score) compared with women with TO.


Subjects:
[+]
Adult Aged Apgar Score Cohort Studies Comorbidity Fallopian Tube Diseases Female Humans Infertility, Female Maternal Age Middle Aged Mothers Polycystic Ovary Syndrome Pregnancy Pregnancy Outcome Prevalence Reproductive Techniques, Assisted Retrospective Studies Risk Factors Treatment Outcome White People
Source:
Fertil Steril. 101(4):1019-1025.
Pubmed ID:
24484993
Pubmed Central ID:
PMC4701028
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Place as Subject:
United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:3b168bd0a4ff0d1fc4c5b95ebc6e315eeecee46e2c2f8d27c99e4ab298dabc28
Download URL:
https://stacks.cdc.gov/view/cdc/37258/cdc_37258_DS1.pdf
File Type:

Supporting Files

• nihms652110.nxml

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