Welcome to CDC Stacks | The molecular constituents of the blood-brain barrier - 37204 | CDC Public Access
Stacks Logo
Advanced Search
Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.
 
 
Help
Clear All Simple Search
Advanced Search
The molecular constituents of the blood-brain barrier
Filetype[PDF - 687.57 KB]


Details:
  • Pubmed ID:
    26442694
  • Pubmed Central ID:
    PMC4597316
  • Funding:
    1DP1NS092473-01/DP/NCCDPHP CDC HHS/United States
    DP1 NS092473/NS/NINDS NIH HHS/United States
    R01 NS064583/NS/NINDS NIH HHS/United States
  • Document Type:
  • Collection(s):
  • Description:
    The blood-brain barrier (BBB) maintains the optimal microenvironment in the central nervous system (CNS) for proper brain function. The BBB comprises specialized CNS endothelial cells with fundamental molecular properties essential for the function and integrity of the BBB. The restrictive nature of the BBB hinders the delivery of therapeutics for many neurological disorders. In addition, recent evidence shows that BBB dysfunction can precede or hasten the progression of several neurological diseases. Despite the physiological significance of the BBB in health and disease, major discoveries of the molecular regulators of BBB formation and function have occurred only recently. This review highlights recent findings describing the molecular determinants and core cellular pathways that confer BBB properties on CNS endothelial cells.