Details:

Alternative Title:
Trends Neurosci
Publisher's site:
http://dx.doi.org/10.1016/j.tins.2015.08.003
Personal Author:
Chow, Brian Wai ; Gu, Chenghua
Chow, Brian Wai ; Gu, Chenghua Less -
Description:
The blood-brain barrier (BBB) maintains the optimal microenvironment in the central nervous system (CNS) for proper brain function. The BBB comprises specialized CNS endothelial cells with fundamental molecular properties essential for the function and integrity of the BBB. The restrictive nature of the BBB hinders the delivery of therapeutics for many neurological disorders. In addition, recent evidence shows that BBB dysfunction can precede or hasten the progression of several neurological diseases. Despite the physiological significance of the BBB in health and disease, major discoveries of the molecular regulators of BBB formation and function have occurred only recently. This review highlights recent findings describing the molecular determinants and core cellular pathways that confer BBB properties on CNS endothelial cells.
Subjects:
[+]
Animals Article Blood-brain Barrier Humans
Source:
Trends Neurosci. 38(10):598-608.
Pubmed ID:
26442694
Pubmed Central ID:
PMC4597316
Document Type:
Journal Article
Funding:
1DP1NS092473-01/DP/NCCDPHP CDC HHS/United States ; DP1 NS092473/NS/NINDS NIH HHS/United States ; R01 NS064583/NS/NINDS NIH HHS/United States
1DP1NS092473-01/DP/NCCDPHP CDC HHS/United States ; DP1 NS092473/NS/NINDS NIH HHS/United States ; R01 NS064583/NS/NINDS NIH HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:3572058fd4c19ac700ac500f74ae07d86a1323e2d6fa9edf85ddb7b658027479
Download URL:
https://stacks.cdc.gov/view/cdc/37204/cdc_37204_DS1.pdf
File Type:

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