Dermal permeation of 2-hydroxypropyl acrylate, a model water-miscible
compound: Effects of concentration, thermodynamic activity and skin
hydration

Frasch, H. Frederick; Barbero, Ana M.; Dotson, G. Scott; Bunge, Annette L.

doi:10.1016/j.ijpharm.2013.11.007

i

Dermal permeation of 2-hydroxypropyl acrylate, a model water-miscible compound: Effects of concentration, thermodynamic activity and skin hydration

Supporting Files

Nov 12 2013
By Frasch, H. Frederick ; Barbero, Ana M. ; Dotson, G. Scott ; ...

Details

Alternative Title:

Int J Pharm
Personal Author:

Frasch, H. Frederick ; Barbero, Ana M. ; Dotson, G. Scott ; Bunge, Annette L.
Description:

Methods

In vitro permeation from HPA-H2O binary mixtures through human epidermis and silicone membranes was measured. Thermodynamic activities of HPA and H2O in these mixtures were determined. Permeation was also measured through epidermis and silicone from donor solutions with constant HPA activity but different H2O activities. Water uptake into desiccated human stratum corneum (SC) equilibrated with HPA-H2O mixtures was determined.

Results

Steady-state flux of HPA through silicone was a linear function of HPA activity but not HPA concentration. For epidermis on the other hand, flux increased with HPA activity only for HPA activities ≤ 0.35. At constant HPA activity, flux decreased 4.5-fold as water activity decreased from 1 to 0.8. Incubation of SC with HPA-H2O mixtures resulted in substantial changes in SC water content, dependent on the water activity of the mixture and consistent with measured SC water sorption data.

Conclusions

These experiments provide unequivocal evidence of a substantial increase in epidermal barrier function resulting from SC dehydration. Dehydration-related alterations in the SC appear responsible for the observed flux characteristics.
Subjects:

Acrylates Acrylic Monomers Adult Article Desiccation Epidermis Female Humans In Vitro Techniques Lag Time Middle Aged Permeability Silicone Elastomers Skin Absorption Skin Hydration Stratum Corneum Thermodynamic Activity Thermodynamics Water
Source:

Int J Pharm. 460(0):240-247.
Pubmed ID:

24239832
Pubmed Central ID:

PMC4685461
Document Type:

Journal Article
Funding:

CC999999/Intramural CDC HHS/United States
Volume:

460
Collection(s):

CDC Public Access
Main Document Checksum:

urn:sha256:ed270f312222e2422eed9a4677483e4fdd11511c5587e63433323ee4c665564d
Download URL:

https://stacks.cdc.gov/view/cdc/36985/cdc_36985_DS1.pdf
File Type:

[PDF - 1.15 MB ]

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