Higher frequency of genetic variants conferring increased risk for ADRs for commonly used drugs treating cancer, AIDS and tuberculosis in persons of African descent

Aminkeng, F; Ross, CJD; Rassekh, SR; Brunham, LR; Sistonen, J; Dube, M-P; Ibrahim, M; Nyambo, TB; Omar, SA; Froment, A; Bodo, J-M; Tishkoff, S; Carleton, BC; Hayden, MR

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Higher frequency of genetic variants conferring increased risk for ADRs for commonly used drugs treating cancer, AIDS and tuberculosis in persons of African descent

Published Date:

Apr 16 2013

Source:

Pharmacogenomics J. 14(2):160-170.

[PDF - 543.67 KB]

Details:

Personal Authors:

Aminkeng, F ; Ross, CJD ; Rassekh, SR ; Brunham, LR ; Sistonen, J ; ... More ▼

Corporate Authors:

The Canadian Pharmacogenomics Network for Drug Safety Consortium

Keywords:

[+]

Pubmed ID:

23588107

Pubmed Central ID:

PMC4684079

Description:

There is established clinical evidence for differences in drug response, cure rates and survival outcomes between different ethnic populations, but the causes are poorly understood. Differences in frequencies of functional genetic variants in key drug response and metabolism genes may significantly influence drug response differences in different populations. To assess this, we genotyped 1330 individuals of African (n=372) and European (n=958) descent for 4535 single-nucleotide polymorphisms in 350 key drug absorption, distribution, metabolism, elimination and toxicity genes. Important and remarkable differences in the distribution of genetic variants were observed between Africans and Europeans and among the African populations. These could translate into significant differences in drug efficacy and safety profiles, and also in the required dose to achieve the desired therapeutic effect in different populations. Our data points to the need for population-specific genetic variation in personalizing medicine and care.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

8 DP1 ES022577-04/DP/NCCDPHP CDC HHS/United States
DP1 ES022577/ES/NIEHS NIH HHS/United States
R01 GM076637/GM/NIGMS NIH HHS/United States
R01GM076637/GM/NIGMS NIH HHS/United States
Canadian Institutes of Health Research/Canada

Supporting Files:

NIHMS740102-supplement-Supplementary_Table_1.xls	application/vnd.ms-excel
NIHMS740102-supplement-Supplementary_Table_2.xls	application/vnd.ms-excel
NIHMS740102-supplement-Supplementary_Table_3.xls	application/vnd.ms-excel
NIHMS740102-supplement-Supplementary_Table_4.xls	application/vnd.ms-excel
NIHMS740102-supplement-Supplementary_Table_5.xls	application/vnd.ms-excel
nihms740102.nxml	application/octet-stream

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