Higher frequency of genetic variants conferring increased risk for ADRs for commonly used drugs treating cancer, AIDS and tuberculosis in persons of African descent

Aminkeng, F; Ross, CJD; Rassekh, SR; Brunham, LR; Sistonen, J; Dube, M-P; Ibrahim, M; Nyambo, TB; Omar, SA; Froment, A; Bodo, J-M; Tishkoff, S; Carleton, BC; Hayden, MR

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Higher frequency of genetic variants conferring increased risk for ADRs for commonly used drugs treating cancer, AIDS and tuberculosis in persons of African descent

Published Date:

Apr 16 2013

Source:

Pharmacogenomics J. 14(2):160-170.

[PDF-543.67 KB]

Details:

Personal Authors:

Aminkeng, F ; Ross, CJD ; Rassekh, SR ; Brunham, LR ; Sistonen, J ; ... More ▼

Corporate Authors:

The Canadian Pharmacogenomics Network for Drug Safety Consortium

Keywords:

[+]

Pubmed ID:

23588107

Pubmed Central ID:

PMC4684079

Description:

There is established clinical evidence for differences in drug response, cure rates and survival outcomes between different ethnic populations, but the causes are poorly understood. Differences in frequencies of functional genetic variants in key drug response and metabolism genes may significantly influence drug response differences in different populations. To assess this, we genotyped 1330 individuals of African (n=372) and European (n=958) descent for 4535 single-nucleotide polymorphisms in 350 key drug absorption, distribution, metabolism, elimination and toxicity genes. Important and remarkable differences in the distribution of genetic variants were observed between Africans and Europeans and among the African populations. These could translate into significant differences in drug efficacy and safety profiles, and also in the required dose to achieve the desired therapeutic effect in different populations. Our data points to the need for population-specific genetic variation in personalizing medicine and care.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

8 DP1 ES022577-04/DP/NCCDPHP CDC HHS/United States
DP1 ES022577/ES/NIEHS NIH HHS/United States
R01 GM076637/GM/NIGMS NIH HHS/United States
R01GM076637/GM/NIGMS NIH HHS/United States
Canadian Institutes of Health Research/Canada

Supporting Files:

	NIHMS740102-supplement-Supplementary_Table_1.xls	application/vnd.ms-excel
	NIHMS740102-supplement-Supplementary_Table_2.xls	application/vnd.ms-excel
	NIHMS740102-supplement-Supplementary_Table_3.xls	application/vnd.ms-excel
	NIHMS740102-supplement-Supplementary_Table_4.xls	application/vnd.ms-excel
	NIHMS740102-supplement-Supplementary_Table_5.xls	application/vnd.ms-excel
	nihms740102.nxml	application/octet-stream

No Related Documents.

You May Also Like:

Adverse Drug Reactions Causing Admission to Medical Wards

Personal Author:

Mouton, Johannes P.; Njuguna, Christine; Kramer, Nicole; Stewart, Annemie; Mehta, Ushma; Blockman, Marc; Fortuin-De Smidt, Melony; De Waal, Reneé; Parrish, Andy G.; Wilson, Douglas P.K.; Igumbor, Ehimario U.; Aynalem, Getahun; Dheda, Mukesh; Maartens, Gary; Cohen, Karen;

Published:

May 2016

Source:

Medicine (Baltimore). 2016; 95(19).

Description:

Limited data exist on the burden of serious adverse drug reactions (ADRs) in sub-Saharan Africa, which has high HIV and tuberculosis prevalence. We determined the proportion of adult admissions attributable to ADRs at 4 hospitals in South Africa. We ...

File Type:

[PDF - 260.99 KB]
Molecular population genetic analysis of emerged bacterial pathogens: selected insights.

Personal Author:

Musser, J. M.

Published:

1996 Jan-Mar

Source:

Emerg Infect Dis. 2(1):1-17.

Description:

Research in bacterial population genetics has increased in the last 10 years. Population genetic theory and tools and related strategies have been used to investigate bacterial pathogens that have contributed to recent episodes of temporal variation ...

File Type:

[PDF - 163.49 KB]
Adverse Drug Reactions Reported to a National HIV & Tuberculosis Health Care Worker Hotline in South Africa: Description and Prospective Follow-Up of Reports

Personal Author:

Njuguna, Christine; Stewart, Annemie; Mouton, Johannes P.; Blockman, Marc; Maartens, Gary; Swart, Annoesjka; Chisholm, Briony; Jones, Jackie; Dheda, Mukesh; Igumbor, Ehimario U.; Cohen, Karen;

Published:

Feb 2016

Source:

Drug Saf. 39(2):159-169.

Description:

Introduction : The National HIV & Tuberculosis Health Care Worker (HCW) Hotline provides advice on the management of suspected adverse drug reactions (ADRs). We describe suspected ADRs reported to the hotline by HCWs, concordance with advice, and...

File Type:

[PDF - 339.22 KB]
Inventory of projects : Progress report: Implementation of A Public Health Action Plan To Combat Antimicrobial Resistance : progress through 2008

Corporate Author:

United States. Interagency Task Force on Antimicrobial Resistance.

Published:

December 29, 2009

Description:

Last revised: December 29, 2009

File Type:

[PDF - 1.11 MB]
Characterizing Genetic Risk at Known Prostate Cancer Susceptibility Loci in African Americans

Personal Author:

Haiman, Christopher A.; Chen, Gary K.; Blot, William J.; Strom, Sara S.; Berndt, Sonja I.; Kittles, Rick A.; Rybicki, Benjamin A.; Isaacs, William B.; Ingles, Sue A.; Stanford, Janet L.; Diver, W. Ryan; Witte, John S.; Chanock, Stephen J.; Kolb, Suzanne; Signorello, Lisa B.; Yamamura, Yuko; Neslund-Dudas, Christine; Thun, Michael J.; Murphy, Adam; Casey, Graham; Sheng, Xin; Wan, Peggy; Pooler, Loreall C.; Monroe, Kristine R.; Waters, Kevin M.; Le Marchand, Loic; Kolonel, Laurence N.; Stram, Daniel O.; Henderson, Brian E.;

Published:

May 26 2011

Source:

PLoS Genet. 2011; 7(5).

Description:

GWAS of prostate cancer have been remarkably successful in revealing common genetic variants and novel biological pathways that are linked with its etiology. A more complete understanding of inherited susceptibility to prostate cancer in the general ...

File Type:

[PDF - 401.98 KB]