Higher frequency of genetic variants conferring increased risk for ADRs for commonly used drugs treating cancer, AIDS and tuberculosis in persons of African descent

Aminkeng, F; Ross, CJD; Rassekh, SR; Brunham, LR; Sistonen, J; Dube, M-P; Ibrahim, M; Nyambo, TB; Omar, SA; Froment, A; Bodo, J-M; Tishkoff, S; Carleton, BC; Hayden, MR

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Higher frequency of genetic variants conferring increased risk for ADRs for commonly used drugs treating cancer, AIDS and tuberculosis in persons of African descent

Published Date:

Apr 16 2013

Source:

Pharmacogenomics J. 14(2):160-170.

[PDF-543.67 KB]

Details:

Alternative Title:

Pharmacogenomics J

Personal Author:

Aminkeng, F ; Ross, CJD ; Rassekh, SR ; Brunham, LR ; Sistonen, J ; ... More ▼

Corporate Authors:

The Canadian Pharmacogenomics Network for Drug Safety Consortium

Description:

There is established clinical evidence for differences in drug response, cure rates and survival outcomes between different ethnic populations, but the causes are poorly understood. Differences in frequencies of functional genetic variants in key drug response and metabolism genes may significantly influence drug response differences in different populations. To assess this, we genotyped 1330 individuals of African (n=372) and European (n=958) descent for 4535 single-nucleotide polymorphisms in 350 key drug absorption, distribution, metabolism, elimination and toxicity genes. Important and remarkable differences in the distribution of genetic variants were observed between Africans and Europeans and among the African populations. These could translate into significant differences in drug efficacy and safety profiles, and also in the required dose to achieve the desired therapeutic effect in different populations. Our data points to the need for population-specific genetic variation in personalizing medicine and care.

Subject:

[+]

Pubmed ID:

23588107

Pubmed Central ID:

PMC4684079

Document Type:

Journal Article

Funding:

8 DP1 ES022577-04/DP/NCCDPHP CDC HHS/United States ; DP1 ES022577/ES/NIEHS NIH HHS/United States ; R01 GM076637/GM/NIGMS NIH HHS/United States ; R01GM076637/GM/NIGMS NIH HHS/United States ; Canadian Institutes of Health Research/Canada ;

Collection(s):

CDC Public Access

Main Document Checksum:

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Supporting Files:

	NIHMS740102-supplement-Supplementary_Table_1.xls	application/vnd.ms-excel
	NIHMS740102-supplement-Supplementary_Table_2.xls	application/vnd.ms-excel
	NIHMS740102-supplement-Supplementary_Table_3.xls	application/vnd.ms-excel
	NIHMS740102-supplement-Supplementary_Table_4.xls	application/vnd.ms-excel
	NIHMS740102-supplement-Supplementary_Table_5.xls	application/vnd.ms-excel
	nihms740102.nxml	application/octet-stream

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