Use of vaccines as probes to define disease burden

Feikin, Daniel R; Scott, J Anthony G; Gessner, Bradford D

doi:10.1016/S0140-6736(13)61682-7

i

Use of vaccines as probes to define disease burden

Supporting Files

Feb 17 2014
By Feikin, Daniel R ; Scott, J Anthony G ; Gessner, Bradford D

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Alternative Title:

Lancet
Personal Author:

Feikin, Daniel R ; Scott, J Anthony G ; Gessner, Bradford D
Description:

Vaccine probe studies have emerged in the past 15 years as a useful way to characterise disease. By contrast, traditional studies of vaccines focus on defining the vaccine effectiveness or efficacy. The underlying basis for the vaccine probe approach is that the difference in disease burden between vaccinated and unvaccinated individuals can be ascribed to the vaccine-specific pathogen. Vaccine probe studies can increase understanding of a vaccine's public health value. For instance, even when a vaccine has a seemingly low efficacy, a high baseline disease incidence can lead to a large vaccine-preventable disease burden and thus that population-based vaccine introduction would be justified. So far, vaccines have been used as probes to characterise disease syndromes caused by Haemophilus influenzae type b, pneumococcus, rotavirus, and early infant influenza. However, vaccine probe studies have enormous potential and could be used more widely in epidemiology, for example, to define the vaccine-preventable burden of malaria, typhoid, paediatric influenza, and dengue, and to identify causal interactions between different pathogens.
Subjects:

Article Communicable Disease Control Communicable Diseases Cost Of Illness Developing Countries Humans Influenza, Human Influenza Vaccines Pneumococcal Vaccines Pneumonia, Pneumococcal Randomized Controlled Trials As Topic Research Design Rotavirus Infections Vaccines Viral Vaccines
Source:

Lancet. 383(9930):1762-1770.
Pubmed ID:

24553294
Pubmed Central ID:

PMC4682543
Document Type:

Journal Article
Funding:

092654/Wellcome Trust/United Kingdom ; 098532/Wellcome Trust/United Kingdom ; CC999999/Intramural CDC HHS/United States
Volume:

383
Issue:

9930
Collection(s):

CDC Public Access
Main Document Checksum:

urn:sha256:ff195ec460b2c8dcdfdd5638a3b3e3eaaedd4f970fc661ee382b7c9e02b076fb
Download URL:

https://stacks.cdc.gov/view/cdc/36900/cdc_36900_DS1.pdf
File Type:

[PDF - 203.93 KB ]

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