Recurrent Kawasaki disease, United States and Japan

Details

• Alternative Title:
  Pediatr Int
• Personal Author:
  Maddox, Ryan A. ; Holman, Robert C. ; Uehara, Ritei ; Callinan, Laura S. ; Guest, Jodie L. ; Schonberger, Lawrence B. ; Nakamura, Yosikazu ; Yashiro, Mayumi ; Belay, Ermias D.
• Description:
  Background
  
  Descriptive epidemiologic studies of recurrent and non-recurrent Kawasaki disease (KD) may identify other potentially important differences between these illnesses.
  
  Methods
  
  Data from the United States and Japan, the Centers for Disease Control and Prevention (CDC) national KD surveillance (1984–2008) and the 17th Japanese nationwide survey (2001–2002), respectively, were analyzed to examine recurrent KD patients <18 years of age meeting the CDC KD case or atypical KD case definition. These patients were compared to non-recurrent KD patients.
  
  Results
  
  Of the 5557 US KD patients <18 years of age during 1984–2008, 97 (1.7%) were identified as having had recurrent KD. Among the US Asian/Pacific Islander KD patients, 3.5% had recurrent KD, which was similar to the percentage identified among KD patients (3.5%) in the Japanese survey. Compared to non-recurrent KD patients, KD patients experiencing a recurrent KD episode were more likely to be older, fulfill the atypical KD case definition, and have coronary artery abnormalities (CAA) despite IVIG treatment.
  
  Conclusions
  
  Differences in the age, race, and frequency of CAA exist between recurrent and non-recurrent KD patients. The increased association of CAA with recurrent KD suggests that more aggressive treatment strategies in conjunction with IVIG may be indicated for the second episode of KD.
  
  
• Subjects:
  Article Epidemiology Kawasaki Disease Kawasaki Syndrome Mucocutaneous Lymph Node Syndrome Recurrence
• Source:
  Pediatr Int. 57(6):1116-1120.
• Pubmed ID:
  26096590
• Pubmed Central ID:
  PMC4676732
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States
• Volume:
  57
• Issue:
  6
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:7e349a70761af1b647c3e5d00f3b96463e36135f072eb170e3ac3e2e25e6a8bb
• Download URL:
  https://stacks.cdc.gov/view/cdc/36811/cdc_36811_DS1.pdf
• File Type:
  [PDF - 142.85 KB ]